Show simple item record

dc.contributor.authorWiesenborn, Denise S
dc.contributor.authorGálvez, Eric J C
dc.contributor.authorSpinel, Lina
dc.contributor.authorVictoria, Berta
dc.contributor.authorAllen, Brittany
dc.contributor.authorSchneider, Augusto
dc.contributor.authorGesing, Adam
dc.contributor.authorAl-Regaiey, Khalid A
dc.contributor.authorStrowig, Till
dc.contributor.authorSchäfer, Karl-Herbert
dc.contributor.authorMasternak, Michal M
dc.identifier.citationJ Gerontol A Biol Sci Med Sci. 2019 Oct 30. pii: 5609456. doi: 10.1093/gerona/glz236.en_US
dc.description.abstractThe gut microbiome (GM) represents a large and very complex ecosystem of different microorganisms. There is an extensive interest in the potential role of the GM in different diseases including cancer, diabetes, cardiovascular diseases, and aging. The GM changes over the lifespan and is strongly associated with various age-related diseases. Ames dwarf (df/df) mice are characterized by an extended life- and healthspan, and although these mice are protected from many age-related diseases, their microbiome has not been studied. To determine the role of microbiota on longevity animal models, we investigated the changes in the GM of df/df and Normal control (N) mice, by comparing parents before mating and littermate mice at three distinct time points during early life. Furthermore, we studied the effects of a 6-month calorie restriction (CR), the most powerful intervention extending the lifespan. Our data revealed significant changes of the GM composition during early life development, and we detected differences in the abundance of some bacteria between df/df and N mice, already in early life. Overall, the variability of the microbiota by genotype, time-point and breeding pair showed significant differences. In addition, CR caused significant changes in microbiome according to gastrointestinal (GI) location (distal colon, ileum and cecum), genotype and diet. However, the overall impact of the genotype was more prominent than that of the CR. In conclusion, our findings suggest that the gut microbiota plays an important role during post-natal development in long-living df/df mice and CR dietary regimen can significantly modulate the GM.en_US
dc.publisherOxford Academicen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.titleThe role of Ames dwarfism and calorie restriction on gut microbiota.en_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalJournals of Gerontology Series Aen_US
dc.source.journaltitleThe journals of gerontology. Series A, Biological sciences and medical sciences

Files in this item

Wiesenborn et al.pdf
accepted manuscript

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International