Show simple item record

dc.contributor.authorGerold, Gisa
dc.contributor.authorMoeller, Rebecca
dc.contributor.authorPietschmann, Thomas
dc.date.accessioned2019-11-27T10:29:34Z
dc.date.available2019-11-27T10:29:34Z
dc.date.issued2019-08-19
dc.identifier.citationCold Spring Harb Perspect Med. 2019 Aug 19. pii: cshperspect.a036830. doi: 10.1101/cshperspect.a036830.en_US
dc.identifier.issn2157-1422
dc.identifier.pmid31427285
dc.identifier.doi10.1101/cshperspect.a036830
dc.identifier.urihttp://hdl.handle.net/10033/622035
dc.description.abstractHepatitis C virus (HCV) entry is among the best-studied uptake processes for human pathogenic viruses. Uptake follows a spatially and temporally tightly controlled program. Numerous host factors including proteins, lipids, and glycans promote productive uptake of HCV particles into human liver cells. The virus initially attaches to surface proteoglycans, lipid receptors such as the scavenger receptor BI (SR-BI), and to the tetraspanin CD81. After lateral translocation of virions to tight junctions, claudin-1 (CLDN1) and occludin (OCLN) are essential for entry. Clathrin-mediated endocytosis engulfs HCV particles, which fuse with endosomal membranes after pH drop. Uncoating of the viral RNA genome in the cytoplasm completes the entry process. Here we systematically review and classify HCV entry factors by their mechanistic role, relevance, and level of evidence. Finally, we report on more recent knowledge on determinants of membrane fusion and close with an outlook on future implications of HCV entry research.en_US
dc.language.isoenen_US
dc.publisherCold Spring Harbor Laboratory Pressen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleHepatitis C Virus Entry: Protein Interactions and Fusion Determinants Governing Productive Hepatocyte Invasion.en_US
dc.typeArticleen_US
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
dc.identifier.journalCold Spring Harbor Perspectives in Medicineen_US
dc.source.journaltitleCold Spring Harbor perspectives in medicine


Files in this item

Thumbnail
Name:
Gerold et al.pdf
Size:
1.299Mb
Format:
PDF
Description:
allowed publisher's PDF after ...

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International