PD-1 expression affects cytokine production by ILC2 and is influenced by peroxisome proliferator-activated receptor-γ.
dc.contributor.author | Batyrova, Banu | |
dc.contributor.author | Luwaert, Fien | |
dc.contributor.author | Maravelia, Panagiota | |
dc.contributor.author | Miyabayashi, Yuria | |
dc.contributor.author | Vashist, Neha | |
dc.contributor.author | Stark, Julian M | |
dc.contributor.author | Soori, Sara Y | |
dc.contributor.author | Tibbitt, Christopher A | |
dc.contributor.author | Riese, Peggy | |
dc.contributor.author | Coquet, Jonathan M | |
dc.contributor.author | Chambers, Benedict J | |
dc.date.accessioned | 2019-12-05T14:14:49Z | |
dc.date.available | 2019-12-05T14:14:49Z | |
dc.date.issued | 2019-11-19 | |
dc.identifier.citation | Immun Inflamm Dis. 2019 Nov 19. doi: 10.1002/iid3.279. | en_US |
dc.identifier.issn | 2050-4527 | |
dc.identifier.pmid | 31742928 | |
dc.identifier.doi | 10.1002/iid3.279 | |
dc.identifier.uri | http://hdl.handle.net/10033/622042 | |
dc.description.abstract | Innate lymphoid cells (ILCs) can provide early cytokine help against a variety of pathogens in the lungs and gastrointestinal tract. Type 2 ILC (ILC2) are comparable to T helper 2 cells found in the adaptive immune system, which secrete cytokines such as interleukin 5 (IL-5) and IL-13 and have been found to play roles in host defense against helminth infections and in allergic responses. Recent studies have identified that programmed cell death protein 1 (PD-1) and peroxisome proliferator activated receptor-γ (PPAR-γ) are highly expressed by ILC2. We examined whether PD-1 plays a role in ILC2 function and whether there was any connection between PD-1 and PPAR-γ METHODS: To ensure that only innate immune cells were present, ILC2 cells were examined from RAG1-/- and PD-1-/- xRAG1-/- mice under steady-state or following inoculation with IL-33. We also tested ILC2 generated from bone marrow of RAG1-/- and PD-1-/- xRAG1-/- mice for their production of cytokines. These in vitro-derived ILC2 were also exposed to agonist and antagonist of PPAR-γ. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | ILC2 | en_US |
dc.subject | cytokine | en_US |
dc.subject | peroxisome proliferator-activated receptor-γ | en_US |
dc.title | PD-1 expression affects cytokine production by ILC2 and is influenced by peroxisome proliferator-activated receptor-γ. | en_US |
dc.type | Article | en_US |
dc.contributor.department | HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany. | en_US |
dc.identifier.journal | Immunity, Inflammation and Disease | en_US |
refterms.dateFOA | 2019-12-05T14:14:50Z | |
dc.source.journaltitle | Immunity, inflammation and disease |