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dc.contributor.authorBatyrova, Banu
dc.contributor.authorLuwaert, Fien
dc.contributor.authorMaravelia, Panagiota
dc.contributor.authorMiyabayashi, Yuria
dc.contributor.authorVashist, Neha
dc.contributor.authorStark, Julian M
dc.contributor.authorSoori, Sara Y
dc.contributor.authorTibbitt, Christopher A
dc.contributor.authorRiese, Peggy
dc.contributor.authorCoquet, Jonathan M
dc.contributor.authorChambers, Benedict J
dc.date.accessioned2019-12-05T14:14:49Z
dc.date.available2019-12-05T14:14:49Z
dc.date.issued2019-11-19
dc.identifier.citationImmun Inflamm Dis. 2019 Nov 19. doi: 10.1002/iid3.279.en_US
dc.identifier.issn2050-4527
dc.identifier.pmid31742928
dc.identifier.doi10.1002/iid3.279
dc.identifier.urihttp://hdl.handle.net/10033/622042
dc.description.abstractInnate lymphoid cells (ILCs) can provide early cytokine help against a variety of pathogens in the lungs and gastrointestinal tract. Type 2 ILC (ILC2) are comparable to T helper 2 cells found in the adaptive immune system, which secrete cytokines such as interleukin 5 (IL-5) and IL-13 and have been found to play roles in host defense against helminth infections and in allergic responses. Recent studies have identified that programmed cell death protein 1 (PD-1) and peroxisome proliferator activated receptor-γ (PPAR-γ) are highly expressed by ILC2. We examined whether PD-1 plays a role in ILC2 function and whether there was any connection between PD-1 and PPAR-γ METHODS: To ensure that only innate immune cells were present, ILC2 cells were examined from RAG1-/- and PD-1-/- xRAG1-/- mice under steady-state or following inoculation with IL-33. We also tested ILC2 generated from bone marrow of RAG1-/- and PD-1-/- xRAG1-/- mice for their production of cytokines. These in vitro-derived ILC2 were also exposed to agonist and antagonist of PPAR-γ.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectILC2en_US
dc.subjectcytokineen_US
dc.subjectperoxisome proliferator-activated receptor-γen_US
dc.titlePD-1 expression affects cytokine production by ILC2 and is influenced by peroxisome proliferator-activated receptor-γ.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalImmunity, Inflammation and Diseaseen_US
refterms.dateFOA2019-12-05T14:14:50Z
dc.source.journaltitleImmunity, inflammation and disease


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