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dc.contributor.authorCheng, Tian
dc.contributor.authorChepkirui, Clara
dc.contributor.authorDecock, Cony
dc.contributor.authorMatasyoh, Josphat C
dc.contributor.authorStadler, Marc
dc.date.accessioned2019-12-19T13:09:49Z
dc.date.available2019-12-19T13:09:49Z
dc.date.issued2019-01-01
dc.identifier.citationBeilstein J Org Chem. 2019 Nov 19;15:2782-2789. doi: 10.3762/bjoc.15.270. eCollection 2019.en_US
dc.identifier.issn1860-5397
dc.identifier.pmid31807212
dc.identifier.doi10.3762/bjoc.15.270
dc.identifier.urihttp://hdl.handle.net/10033/622051
dc.description.abstractDuring the course of screening for new metabolites from basidiomycetes, we isolated and characterized five previously undescribed secondary metabolites, skeletocutins M-Q (1-5), along with the known metabolite tyromycin A (6) from the fruiting bodies of the polypore Skeletocutis sp. The new compounds did not exhibit any antimicrobial, cytotoxic, or nematicidal activities. However, compound 3 moderately inhibited the biofilm formation of Staphylococcus aureus (S. aureus), while compounds 3 and 4 performed moderately in the ʟ-leucine-7-amido-4-methylcoumarin (ʟ-Leu-AMC) inhibition assay. These compounds represent the first secondary metabolites reported to occur in the fruiting bodies by Skeletocutis. Interestingly, tyromycin A (6) was found to be the only common metabolite in fruiting bodies and mycelial cultures of the fungus, and none of the recently reported skeletocutins from the culture of the same strain were detected in the basidiomes.en_US
dc.language.isoenen_US
dc.publisherBeilstein Instituten_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectbasidiomyceteen_US
dc.subjectpolyporaceaeen_US
dc.subjectsecondary metabolitesen_US
dc.subjectstructure elucidationen_US
dc.titleSkeletocutins M-Q: biologically active compounds from the fruiting bodies of the basidiomycete Skeletocutis sp. collected in Africa.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalBeilstein Journal of Organic Chemistryen_US
refterms.dateFOA2019-12-19T13:09:49Z
dc.source.journaltitleBeilstein journal of organic chemistry


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