Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment.
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Authors
Siemens, NikolaiOehmcke-Hecht, Sonja
Hoßmann, Jörn
Skorka, Sebastian B
Nijhuis, Roel H T
Ruppen, Corinne
Skrede, Steinar
Rohde, Manfred
Schultz, Daniel
Lalk, Michael
Itzek, Andreas
Pieper, Dietmar H
van den Bout, Christiaan J
Claas, Eric C J
Kuijper, Ed J
Mauritz, Robert
Sendi, Parham
Wunderink, Herman F
Norrby-Teglund, Anna
Issue Date
2019-11-19
Metadata
Show full item recordAbstract
A prominent feature of severe streptococcal infections is the profound inflammatory response that contributes to systemic toxicity. In sepsis the dysregulated host response involves both immunological and nonimmunological pathways. Here, we report a fatal case of an immunocompetent healthy female presenting with toxic shock and purpura fulminans caused by group B streptococcus (GBS; serotype III, CC19). The strain (LUMC16) was pigmented and hyperhemolytic. Stimulation of human primary cells with hyperhemolytic LUMC16 and STSS/NF-HH strains and pigment toxin resulted in a release of proinflammatory mediators, including tumor necrosis factor, interleukin (IL)-1β, and IL-6. In addition, LUMC16 induced blood clotting and showed factor XII activity on its surface, which was linked to the presence of the pigment. The expression of pigment was not linked to a mutation within the CovR/S region. In conclusion, our study shows that the hemolytic lipid toxin contributes to the ability of GBS to cause systemic hyperinflammation and interferes with the coagulation system.Citation
J Innate Immun. 2019 Nov 19:1-13. doi: 10.1159/000504002.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
KargerJournal
Journal of Innate ImmunityPubMed ID
31743913Type
ArticleISSN
1662-8128ae974a485f413a2113503eed53cd6c53
10.1159/000504002
Scopus Count
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- Creative Commons
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