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dc.contributor.authorSiemens, Nikolai
dc.contributor.authorOehmcke-Hecht, Sonja
dc.contributor.authorHoßmann, Jörn
dc.contributor.authorSkorka, Sebastian B
dc.contributor.authorNijhuis, Roel H T
dc.contributor.authorRuppen, Corinne
dc.contributor.authorSkrede, Steinar
dc.contributor.authorRohde, Manfred
dc.contributor.authorSchultz, Daniel
dc.contributor.authorLalk, Michael
dc.contributor.authorItzek, Andreas
dc.contributor.authorPieper, Dietmar H
dc.contributor.authorvan den Bout, Christiaan J
dc.contributor.authorClaas, Eric C J
dc.contributor.authorKuijper, Ed J
dc.contributor.authorMauritz, Robert
dc.contributor.authorSendi, Parham
dc.contributor.authorWunderink, Herman F
dc.contributor.authorNorrby-Teglund, Anna
dc.date.accessioned2020-01-03T12:44:26Z
dc.date.available2020-01-03T12:44:26Z
dc.date.issued2019-11-19
dc.identifier.citationJ Innate Immun. 2019 Nov 19:1-13. doi: 10.1159/000504002.en_US
dc.identifier.issn1662-8128
dc.identifier.pmid31743913
dc.identifier.doi10.1159/000504002
dc.identifier.urihttp://hdl.handle.net/10033/622058
dc.description.abstractA prominent feature of severe streptococcal infections is the profound inflammatory response that contributes to systemic toxicity. In sepsis the dysregulated host response involves both immunological and nonimmunological pathways. Here, we report a fatal case of an immunocompetent healthy female presenting with toxic shock and purpura fulminans caused by group B streptococcus (GBS; serotype III, CC19). The strain (LUMC16) was pigmented and hyperhemolytic. Stimulation of human primary cells with hyperhemolytic LUMC16 and STSS/NF-HH strains and pigment toxin resulted in a release of proinflammatory mediators, including tumor necrosis factor, interleukin (IL)-1β, and IL-6. In addition, LUMC16 induced blood clotting and showed factor XII activity on its surface, which was linked to the presence of the pigment. The expression of pigment was not linked to a mutation within the CovR/S region. In conclusion, our study shows that the hemolytic lipid toxin contributes to the ability of GBS to cause systemic hyperinflammation and interferes with the coagulation system.en_US
dc.publisherKargeren_US
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/305340en_US
dc.rightsopenAccessen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectCoagulationen_US
dc.subjectGroup B streptococcusen_US
dc.subjectHemolysisen_US
dc.subjectInflammationen_US
dc.subjectPigmenten_US
dc.subjectStreptococcus agalactiaeen_US
dc.titleProthrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalJournal of Innate Immunityen_US
refterms.dateFOA2020-01-03T12:44:26Z
dc.source.journaltitleJournal of innate immunity


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