Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
MetadataShow full item record
AbstractThe Amyloid Precursor Protein (APP) is infamous for its proposed pivotal role in the pathogenesis of Alzheimer’s disease (AD). Much research on APP focusses on potential contributions to neurodegeneration, mostly based on mouse models with altered expression or mutated forms of APP. However, cumulative evidence from recent years indicates the indispensability of APP and its metabolites for normal brain physiology. APP contributes to the regulation of synaptic transmission, plasticity, and calcium homeostasis. It plays an important role during development and it exerts neuroprotective effects. Of particular importance is the soluble secreted fragment APPsα which mediates many of its physiological actions, often counteracting the effects of the small APP-derived peptide Aβ. Understanding the contribution of APP for normal functions of the nervous system is of high importance, both from a basic science perspective and also as a basis for generating new pathophysiological concepts and therapeutic approaches in AD. In this article, we review the physiological functions of APP and its metabolites, focusing on synaptic transmission, plasticity, calcium signaling, and neuronal network activity.
CitationNeuroscientist. 2019 Nov 29:1073858419882619. doi: 10.1177/1073858419882619.
AffiliationHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
- Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory.
- Authors: Turner PR, O'Connor K, Tate WP, Abraham WC
- Issue date: 2003 May
- Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP.
- Authors: Wang Z, Jackson RJ, Hong W, Taylor WM, Corbett GT, Moreno A, Liu W, Li S, Frosch MP, Slutsky I, Young-Pearse TL, Spires-Jones TL, Walsh DM
- Issue date: 2017 Dec 6
- From synaptic spines to nuclear signaling: nuclear and synaptic actions of the amyloid precursor protein.
- Authors: Octave JN, Pierrot N, Ferao Santos S, Nalivaeva NN, Turner AJ
- Issue date: 2013 Jul
- The Amyloid Precursor Protein Intracellular Domain Is an Effector Molecule of Metaplasticity.
- Authors: Trillaud-Doppia E, Boehm J
- Issue date: 2018 Mar 1
- The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models.
- Authors: Korte M, Herrmann U, Zhang X, Draguhn A
- Issue date: 2012 Apr