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dc.contributor.authorHefter, Dimitri
dc.contributor.authorLudewig, Susann
dc.contributor.authorDraguhn, Andreas
dc.contributor.authorKorte, Martin
dc.date.accessioned2020-01-03T14:27:43Z
dc.date.available2020-01-03T14:27:43Z
dc.date.issued2019-11-29
dc.identifier.citationNeuroscientist. 2019 Nov 29:1073858419882619. doi: 10.1177/1073858419882619.en_US
dc.identifier.issn1089-4098
dc.identifier.pmid31779518
dc.identifier.doi10.1177/1073858419882619
dc.identifier.urihttp://hdl.handle.net/10033/622061
dc.description.abstractThe Amyloid Precursor Protein (APP) is infamous for its proposed pivotal role in the pathogenesis of Alzheimer’s disease (AD). Much research on APP focusses on potential contributions to neurodegeneration, mostly based on mouse models with altered expression or mutated forms of APP. However, cumulative evidence from recent years indicates the indispensability of APP and its metabolites for normal brain physiology. APP contributes to the regulation of synaptic transmission, plasticity, and calcium homeostasis. It plays an important role during development and it exerts neuroprotective effects. Of particular importance is the soluble secreted fragment APPsα which mediates many of its physiological actions, often counteracting the effects of the small APP-derived peptide Aβ. Understanding the contribution of APP for normal functions of the nervous system is of high importance, both from a basic science perspective and also as a basis for generating new pathophysiological concepts and therapeutic approaches in AD. In this article, we review the physiological functions of APP and its metabolites, focusing on synaptic transmission, plasticity, calcium signaling, and neuronal network activity.en_US
dc.language.isoenen_US
dc.publisherSage Publikationsen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAPPen_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectamyloiden_US
dc.subjectoscillationsen_US
dc.subjectplasticityen_US
dc.subjectsynaptic transmissionen_US
dc.titleAmyloid, APP, and Electrical Activity of the Brain.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalThe neuroscientisten_US
refterms.dateFOA2020-01-03T14:27:44Z
dc.source.journaltitleThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry


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Attribution-NonCommercial-ShareAlike 4.0 International
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