The NF-κB transcription factor c-Rel controls host defense against Citrobacter rodentium.
Abstract
Mice lacking CD4+ T cells or B cells are highly susceptible to Citrobacter rodentium infection. In this study, we show that the activity of the transcription factor c-Rel in lymphocytes is crucial for clearance of C. rodentium. Mice deficient for c-Rel fail to generate protective antibodies and to eradicate the pathogen.Citation
Eur J Immunol. 2019 Nov 14. doi: 10.1002/eji.201948314.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
Wiley-VCHJournal
European Journal of ImmunologyPubMed ID
31724737Type
OtherLanguage
enDescription
LetterISSN
1521-4141Scopus Count
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International