Pigmentosins from Gibellula sp. As antibiofilm agents and a new glycosylated asperfuran from Cordyceps javanica
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsHelaly, Soleiman E.
Ibrahim, Mahmoud A.A.
Luangsa-Ard, Janet Jennifer
MetadataShow full item record
Abstractn the course of our exploration of the Thai invertebrate-pathogenic fungi for biologically active metabolites, pigmentosin A (1) and a new bis(naphtho-α-pyrone) derivative, pigmentosin B (2), were isolated from the spider-associated fungus Gibellula sp. Furthermore, a new glycosylated asperfuran 3, together with one new (6) and two known (4 and 5) cyclodepsipeptides, was isolated from Cordyceps javanica. The pigmentosins 1 and 2 showed to be active against biofilm formation of Staphylococcus aureus DSM1104. The lack of toxicity toward the studied microorganism and cell lines of pigmentosin B (2), as well as the antimicrobial effect of pigmentosin A (1), made them good candidates for further development for use in combination therapy of infections involving biofilm-forming S. aureus. The structure elucidation and determination of the absolute configuration were accomplished using a combination of spectroscopy, including 1D and 2D NMR, HRMS, Mosher ester analysis, and comparison of calculated/experimental ECD spectra. A chemotaxonomic investigation of the secondary metabolite profiles using analytical HPLC coupled with diode array detection and mass spectrometry (HPLC–DAD–MS) revealed that the production of pigmentosin B (2) was apparently specific for Gibellula sp., while the glycoasperfuran 3 was specific for C. javanica.
CitationBeilstein J Org Chem. 2019 Dec 16;15:2968-2981. doi: 10.3762/bjoc.15.293. eCollection 2019.
AffiliationHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
- Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis.
- Authors: Helaly SE, Kuephadungphan W, Phongpaichit S, Luangsa-Ard JJ, Rukachaisirikul V, Stadler M
- Issue date: 2017 Jun 14
- Paecilosetin Derivatives as Potent Antimicrobial Agents from <i>Isaria farinosa</i>.
- Authors: Brel O, Touré S, Levasseur M, Lechat C, Pellissier L, Wolfender JL, Van-Elslande E, Litaudon M, Dusfour I, Stien D, Eparvier V
- Issue date: 2020 Oct 23
- Phylogeny- and morphology-based recognition of new species in the spider-parasitic genus <i>Gibellula</i> (Hypocreales, Cordycipitaceae) from Thailand.
- Authors: Kuephadungphan W, Tasanathai K, Petcharad B, Khonsanit A, Stadler M, Luangsa-Ard JJ
- Issue date: 2020
- Transferring Fungi to a Deuterium-Enriched Medium Results in Assorted, Conditional Changes in Secondary Metabolite Production.
- Authors: Wang B, Park EM, King JB, Mattes AO, Nimmo SL, Clendinen C, Edison AS, Anklin C, Cichewicz RH
- Issue date: 2015 Jun 26
- New alkaloidal metabolites from cultures of entomopathogenic fungus Cordyceps takaomontana NBRC 101754.
- Authors: Hama M, Elshamy AI, Yoneyama T, Kasai Y, Yamamoto H, Tanigawa K, Oshiro A, Noji M, Ban S, Imagawa H, Umeyama A
- Issue date: 2019 Nov