Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections.

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Authors
Bergsten, Helena
Madsen, Martin Bruun
Bergey, Francois
Hyldegaard, Ole
Skrede, Steinar
Arnell, Per
Oppegaard, Oddvar
Itzek, Andreas
Perner, Anders
Svensson, Mattias
Issue Date
2020-01-09

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Abstract
Analyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.
Citation
Clin Infect Dis. 2020 Jan 9. pii: 5698680. doi: 10.1093/cid/ciaa022.
Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
Publisher
Oxford University Press
Journal
Clinical Infectious Diseases
URI
http://hdl.handle.net/10033/622089
DOI
10.1093/cid/ciaa022
PubMed ID
31916575
Type
Article
Language
en
ISSN
1537-6591
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