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Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections.

dc.contributor.authorBergsten, Helena
dc.contributor.authorMadsen, Martin Bruun
dc.contributor.authorBergey, Francois
dc.contributor.authorHyldegaard, Ole
dc.contributor.authorSkrede, Steinar
dc.contributor.authorArnell, Per
dc.contributor.authorOppegaard, Oddvar
dc.contributor.authorItzek, Andreas
dc.contributor.authorPerner, Anders
dc.contributor.authorSvensson, Mattias
dc.contributor.authorNorrby-Teglund, Anna
dc.date.accessioned2020-01-17T12:52:34Z
dc.date.available2020-01-17T12:52:34Z
dc.date.issued2020-01-09
dc.identifier.citationClin Infect Dis. 2020 Jan 9. pii: 5698680. doi: 10.1093/cid/ciaa022.en_US
dc.identifier.issn1537-6591
dc.identifier.pmid31916575
dc.identifier.doi10.1093/cid/ciaa022
dc.identifier.urihttp://hdl.handle.net/10033/622089
dc.description.abstractAnalyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectStreptococcus pyogenesen_US
dc.subjectIntravenous immunoglobulin Gen_US
dc.subjectnecrotizing fasciitisen_US
dc.subjectnecrotizing soft tissue infectionsen_US
dc.subjectsuperantigensen_US
dc.titleCorrelation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalClinical Infectious Diseasesen_US
refterms.dateFOA2020-01-17T12:52:36Z
dc.source.journaltitleClinical infectious diseases : an official publication of the Infectious Diseases Society of America


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