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dc.contributor.authorMacabeo, Allan Patrick G.
dc.contributor.authorCruz, Allaine Jean C.
dc.contributor.authorNarmani, Abolfazl
dc.contributor.authorArzanlou, Mahdi
dc.contributor.authorBabai-Ahari, Asadollah
dc.contributor.authorPilapil, Luis Agustin E.
dc.contributor.authorGarcia, Katherine Yasmin M.
dc.contributor.authorHuch, Volker
dc.contributor.authorStadler, Marc
dc.date.accessioned2020-02-04T10:57:25Z
dc.date.available2020-02-04T10:57:25Z
dc.date.issued2020-02
dc.identifier.issn1874-3900
dc.identifier.doi10.1016/j.phytol.2019.11.010
dc.identifier.urihttp://hdl.handle.net/10033/622117
dc.description.abstractTwo new -pyrone derivatives, udagawanones A (1) and B (2), along with the known compounds (Z)-4-hydroxy-3-(3-hydroxy-3-methylbut-1-en-1-yl)benzoic acid (3), isosclerone (4), cyclo-(L-Leu-L-Pro) (5), and cyclo-(L-Pro-L-Tyr) (6), were isolated from cultures of the endophyte Neurospora udagawae. Their structures were elucidated by extensive spectroscopic methods and single crystal X-ray diffraction. Both compounds feature oxidized functionalities at the C-2 position not previously observed in other tetrasubstituted -pyrones from fungi. Compound 1 exhibited moderate antibacterial (vs. Staphylococcus aureus) and antifungal (vs. Rhodoturula glutinis) activities and cytotoxicity against KB3.1 cells.en_US
dc.language.isoenen_US
dc.publisherElsevier BVen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBiotechnologyen_US
dc.subjectAgronomy and Crop Scienceen_US
dc.subjectPlant Scienceen_US
dc.subjectBiochemistryen_US
dc.titleTetrasubstituted α-pyrone derivatives from the endophytic fungus, Neurospora udagawaeen_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalPhytochemistry Lettersen_US
dc.source.volume35
dc.source.beginpage147-151


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