A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.
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Authors
Namineni, SukumarO'Connor, Tracy
Faure-Dupuy, Suzanne
Johansen, Pål
Riedl, Tobias
Liu, Kaijing
Xu, Haifeng
Singh, Indrabahadur
Shinde, Prashant
Li, Fanghui
Pandyra, Aleksandra
Sharma, Piyush
Ringelhan, Marc
Muschaweckh, Andreas
Borst, Katharina
Blank, Patrick
Lampl, Sandra
Durantel, David
Farhat, Rayan
Weber, Achim
Lenggenhager, Daniela
Kündig, Thomas M
Staeheli, Peter
Protzer, Ulrike
Wohlleber, Dirk
Holzmann, Bernhard
Binder, Marco
Breuhahn, Kai
Assmus, Lisa Mareike
Nattermann, Jacob
Abdullah, Zeinab
Rolland, Maude
Dejardin, Emmanuel
Lang, Philipp A
Lang, Karl S
Karin, Michael
Lucifora, Julie
Kalinke, Ulrich
Knolle, Percy A
Heikenwalder, Mathias
Issue Date
2020-01-15
Metadata
Show full item recordAbstract
Using lymphocytic choriomeningitis virus (LCMV) as a model of liver infection, we first assessed the role of myeloid cells by depletion prior to infection. We investigated the role of hepatocyte-intrinsic innate immune signaling by infecting mice lacking canonical NF-κB signaling (IKKβΔHep) specifically in hepatocytes. In addition, mice lacking hepatocyte-specific interferon-α/β signaling-(IFNARΔHep), or interferon-α/β signaling in myeloid cells-(IFNARΔMyel) were infected.Citation
J Hepatol. 2020 Jan 15. pii: S0168-8278(20)30010-6. doi: 10.1016/j.jhep.2019.12.019.Affiliation
TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.Publisher
ElsevierJournal
Journal of HepatologyPubMed ID
31954207Type
ArticleISSN
1600-0641ae974a485f413a2113503eed53cd6c53
10.1016/j.jhep.2019.12.019
Scopus Count
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