Molecular Mechanisms of Vaspin Action - From Adipose Tissue to Skin and Bone, from Blood Vessels to the Brain.
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AbstractVisceral adipose tissue-derived serine protease inhibitor (vaspin) or SERPINA12 according to the serpin nomenclature was identified together with other genes and gene products that were specifically expressed or overexpressed in the intra-abdominal or visceral adipose tissue (AT) of the Otsuka Long-Evans Tokushima fatty rat. These rats spontaneously develop visceral obesity, insulin resistance, hyperinsulinemia and -glycemia, as well as hypertension and thus represent a well suited animal model of obesity and related metabolic disorders such as type 2 diabetes.The follow-up study reporting the cloning, expression and functional characterization of vaspin suggested the great and promising potential of this molecule to counteract obesity induced insulin resistance and inflammation and has since initiated over 300 publications, clinical and experimental, that have contributed to uncover the multifaceted functions and molecular mechanisms of vaspin action not only in the adipose, but in many different cells, tissues and organs. This review will give an update on mechanistic and structural aspects of vaspin with a focus on its serpin function, the physiology and regulation of vaspin expression, and will summarize the latest on vaspin function in various tissues such as the different adipose tissue depots as well as the vasculature, skin, bone and the brain.
CitationAdv Exp Med Biol. 2019;1111:159-188. doi: 10.1007/5584_2018_241.
AffiliationHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
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- Vaspin in obesity and diabetes: pathophysiological and clinical significance.
- Authors: Blüher M
- Issue date: 2012 Apr
- Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity.
- Authors: Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A, Hashimoto I, Okada T, Yasuhara A, Nakatsuka A, Shikata K, Hourai S, Futami J, Watanabe E, Matsuki Y, Hiramatsu R, Akagi S, Makino H, Kanwar YS
- Issue date: 2005 Jul 26
- Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes.
- Authors: Klöting N, Berndt J, Kralisch S, Kovacs P, Fasshauer M, Schön MR, Stumvoll M, Blüher M
- Issue date: 2006 Jan 6
- Vaspin: a novel serpin with insulin-sensitizing effects.
- Authors: Wada J
- Issue date: 2008 Mar
- [Effect of different intensity exercise prescription on visceral adipose Vaspin gene, protein expression and plasma Vaspin concentration in aged obese rats].
- Authors: Lin C, Bai Y, Sun M, Zhang H, Su M, Cui J, Song W, Wu L
- Issue date: 2017 Jan