Coupling quaternary ammonium surfactants to the surface of liposomes improves both antibacterial efficacy and host cell biocompatibility
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Authors
Montefusco-Pereira, Carlos V.Formicola, Beatrice
Goes, Adriely
Re, Francesca
Marrano, Claudia A.
Mantegazza, Francesco
Carvalho-Wodarz, Cristiane
Fuhrmann, Gregor

Caneva, Enrico
Nicotra, Francesco
Lehr, Claus-Michael
Russo, Laura
Issue Date
2020-04
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By functionalizing the surface of PEG-liposomes with linkers bearing quaternary ammonium compounds (QACs), we generated novel bacteria disruptors with anti-adhesive properties and reduced cytotoxicity compared to free QACs. Furthermore, QAC-functionalized liposomes are a promising platform for future drug encapsulation. The QAC (11-mercaptoundecyl)-N,N,N-trimethylammonium bromide (MTAB) was attached to maleimide-functionalized liposomes (DSPE-PEG) via thiol linker. The MTAB-functionalized liposomes were physicochemically characterized and their biological activity, in terms of anti-adherence activity and biofilm prevention in Escherichia coli were assessed. The results showed that MTAB-functionalized liposomes inhibit bacterial adherence and biofilm formation while reducing MTAB toxicity.Citation
Eur J Pharm Biopharm. 2020 Jan 30. pii: S0939-6411(20)30024-2. doi:10.1016/j.ejpb.2020.01.013.Affiliation
HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.Publisher
Elsevier BVPubMed ID
32007589Type
ArticleISSN
0939-6411ae974a485f413a2113503eed53cd6c53
10.1016/j.ejpb.2020.01.013
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