Show simple item record

dc.contributor.authorZorro, Maria Magdalena
dc.contributor.authorAguirre-Gamboa, Raul
dc.contributor.authorMayassi, Toufic
dc.contributor.authorCiszewski, Cezary
dc.contributor.authorBarisani, Donatella
dc.contributor.authorHu, Shixian
dc.contributor.authorWeersma, Rinse K
dc.contributor.authorWithoff, Sebo
dc.contributor.authorLi, Yang
dc.contributor.authorWijmenga, Cisca
dc.contributor.authorJabri, Bana
dc.contributor.authorJonkers, Iris H
dc.date.accessioned2020-02-21T14:27:15Z
dc.date.available2020-02-21T14:27:15Z
dc.date.issued2020-02-04
dc.identifier.citationJ Autoimmun. 2020 Feb 4:102422. doi: 10.1016/j.jaut.2020.102422.en_US
dc.identifier.issn1095-9157
dc.identifier.pmid32033836
dc.identifier.doi10.1016/j.jaut.2020.102422
dc.identifier.urihttp://hdl.handle.net/10033/622160
dc.description.abstractThe respective effects of tissue alarmins interleukin (IL)-15 and interferon beta (IFNβ), and IL-21 produced by T cells on the reprogramming of cytotoxic T lymphocytes (CTLs) that cause tissue destruction in celiac disease is poorly understood. Transcriptomic and epigenetic profiling of primary intestinal CTLs showed massive and distinct temporal transcriptional changes in response to tissue alarmins, while the impact of IL-21 was limited. Only anti-viral pathways were induced in response to all the three stimuli, albeit with differences in dynamics and strength. Moreover, changes in gene expression were primarily independent of changes in H3K27ac, suggesting that other regulatory mechanisms drive the robust transcriptional response. Finally, we found that IL-15/IFNβ/IL-21 transcriptional signatures could be linked to transcriptional alterations in risk loci for complex immune diseases. Together these results provide new insights into molecular mechanisms that fuel the activation of CTLs under conditions that emulate the inflammatory environment in patients with autoimmune diseases.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAutoimmune diseaseen_US
dc.subjectCytotoxic T lymphocytesen_US
dc.subjectIFNβen_US
dc.subjectIL-15en_US
dc.subjectIL-21en_US
dc.subjectIntraepithelial lymphocytesen_US
dc.subjectTissue-resident lymphocytesen_US
dc.titleTissue alarmins and adaptive cytokine induce dynamic and distinct transcriptional responses in tissue-resident intraepithelial cytotoxic T lymphocytes.en_US
dc.typeArticleen_US
dc.contributor.departmentCiiM, Zentrum für individualisierte Infektionsmedizin, Feodor-Lynen-Str.7, 30625 Hannover.en_US
dc.identifier.journalJournal of Autoimmunityen_US
refterms.dateFOA2020-02-21T14:27:16Z
dc.source.journaltitleJournal of autoimmunity


Files in this item

Thumbnail
Name:
Publisher version
Thumbnail
Name:
Zoro et al.pdf
Size:
2.397Mb
Format:
PDF
Description:
Open Access article
Thumbnail
Name:
supplementl files.zip
Size:
4.825Mb
Format:
Unknown
Description:
supplemental files

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International