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dc.contributor.authorMyronovskyi, Maksym
dc.contributor.authorRosenkränzer, Birgit
dc.contributor.authorStierhof, Marc
dc.contributor.authorPetzke, Lutz
dc.contributor.authorSeiser, Tobias
dc.contributor.authorLuzhetskyy, Andriy
dc.date.accessioned2020-02-26T14:12:48Z
dc.date.available2020-02-26T14:12:48Z
dc.date.issued2020-02-10
dc.identifier.citationMicroorganisms. 2020 Feb 10;8(2). pii: microorganisms8020237. doi: 10.3390/microorganisms8020237.en_US
dc.identifier.issn2076-2607
dc.identifier.pmid32050690
dc.identifier.doi10.3390/microorganisms8020237
dc.identifier.urihttp://hdl.handle.net/10033/622177
dc.description.abstractHerbicides with new modes of action and safer toxicological and environmental profiles are needed to manage the evolution of weeds that are resistant to commercial herbicides. The unparalleled structural diversity of natural products makes these compounds a promising source for new herbicides. In 2009, a novel nucleoside phytotoxin, albucidin, with broad activity against grass and broadleaf weeds was isolated from a strain of Streptomyces albus subsp. chlorinus NRRL B-24108. Here, we report the identification and heterologous expression of the previously uncharacterized albucidin gene cluster. Through a series of gene inactivation experiments, a minimal set of albucidin biosynthetic genes was determined. Based on gene annotation and sequence homology, a model for albucidin biosynthesis was suggested. The presented results enable the construction of producer strains for a sustainable supply of albucidin for biological activity studies.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectStreptomyces albus Del14en_US
dc.subjectalbucidinen_US
dc.subjectbiosynthetic gene clusteren_US
dc.subjectherbicideen_US
dc.subjectheterologous expressionen_US
dc.subjectnucleosideen_US
dc.titleIdentification and Heterologous Expression of the Albucidin Gene Cluster from the Marine Strain Subsp. NRRL B-24108.en_US
dc.typeArticleen_US
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalMicroorganismsen_US
refterms.dateFOA2020-02-26T14:12:49Z
dc.source.journaltitleMicroorganisms


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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International