IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival.
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Authors
Knop, LauraDeiser, Katrin
Bank, Ute
Witte, Amelie
Mohr, Juliane
Philipsen, Lars
Fehling, Hans J
Müller, Andreas J
Kalinke, Ulrich

Schüler, Thomas
Issue Date
2020-02-11
Metadata
Show full item recordAbstract
The survival of peripheral T cells is dependent on their access to peripheral lymph nodes (pLNs) and stimulation by Interleukin-7 (IL-7). In pLNs fibroblastic reticular cells (FRCs) and lymphatic endothelial cells (LECs) produce IL-7 suggesting their contribution to the IL-7-dependent survival of T cells. However, IL-7 production is detectable in multiple organs and is not restricted to pLNs. This raises the question whether pLN-derived IL-7 is required for the maintenance of peripheral T cell homeostasis. Here, we show that numbers of naive T cells (TN ) remain unaffected in pLNs and spleen of mice lacking Il7 gene activity in pLN FRCs, LECs or both. In contrast, frequencies of central memory T cells (TCM ) are reduced in FRC-specific IL-7 knockout mice. Thus, steady state IL-7 production by pLN FRCs is critical for the maintenance of TCM , but not TN , indicating that both T cell subsets colonize different ecological niches in vivo. This article is protected by copyright. All rights reserved.Citation
Eur J Immunol. 2020 Feb 11. doi: 10.1002/eji.201948368.Affiliation
TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.Publisher
Wiley Online OpenJournal
European journal of immunologyPubMed ID
32043573Type
ArticleLanguage
enISSN
1521-4141ae974a485f413a2113503eed53cd6c53
10.1002/eji.201948368
Scopus Count
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- Creative Commons
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