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dc.contributor.authorKnop, Laura
dc.contributor.authorDeiser, Katrin
dc.contributor.authorBank, Ute
dc.contributor.authorWitte, Amelie
dc.contributor.authorMohr, Juliane
dc.contributor.authorPhilipsen, Lars
dc.contributor.authorFehling, Hans J
dc.contributor.authorMüller, Andreas J
dc.contributor.authorKalinke, Ulrich
dc.contributor.authorSchüler, Thomas
dc.date.accessioned2020-02-27T09:59:30Z
dc.date.available2020-02-27T09:59:30Z
dc.date.issued2020-02-11
dc.identifier.citationEur J Immunol. 2020 Feb 11. doi: 10.1002/eji.201948368.en_US
dc.identifier.issn1521-4141
dc.identifier.pmid32043573
dc.identifier.doi10.1002/eji.201948368
dc.identifier.urihttp://hdl.handle.net/10033/622180
dc.description.abstractThe survival of peripheral T cells is dependent on their access to peripheral lymph nodes (pLNs) and stimulation by Interleukin-7 (IL-7). In pLNs fibroblastic reticular cells (FRCs) and lymphatic endothelial cells (LECs) produce IL-7 suggesting their contribution to the IL-7-dependent survival of T cells. However, IL-7 production is detectable in multiple organs and is not restricted to pLNs. This raises the question whether pLN-derived IL-7 is required for the maintenance of peripheral T cell homeostasis. Here, we show that numbers of naive T cells (TN ) remain unaffected in pLNs and spleen of mice lacking Il7 gene activity in pLN FRCs, LECs or both. In contrast, frequencies of central memory T cells (TCM ) are reduced in FRC-specific IL-7 knockout mice. Thus, steady state IL-7 production by pLN FRCs is critical for the maintenance of TCM , but not TN , indicating that both T cell subsets colonize different ecological niches in vivo. This article is protected by copyright. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherWiley Online Openen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectT cell homeostasisen_US
dc.subjectcentral memory T cellsen_US
dc.subjectfibroblastic reticular cellsen_US
dc.subjectinterleukin-7en_US
dc.subjectnaive T cellsen_US
dc.titleIL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival.en_US
dc.typeArticleen_US
dc.contributor.departmentTWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany.en_US
dc.identifier.journalEuropean journal of immunologyen_US
refterms.dateFOA2020-02-27T09:59:30Z
dc.source.journaltitleEuropean journal of immunology


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