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dc.contributor.authorAlfonso, Juan Carlos L
dc.contributor.authorPapaxenopoulou, Lito A
dc.contributor.authorMascheroni, Pietro
dc.contributor.authorMeyer-Hermann, Michael
dc.contributor.authorHatzikirou, Haralampos
dc.date.accessioned2020-03-10T13:31:56Z
dc.date.available2020-03-10T13:31:56Z
dc.date.issued2020-02-11
dc.identifier.citationiScience. 2020 Feb 11;23(3):100897. doi: 10.1016/j.isci.2020.100897.en_US
dc.identifier.issn2589-0042
dc.identifier.pmid32092699
dc.identifier.doi10.1016/j.isci.2020.100897
dc.identifier.urihttp://hdl.handle.net/10033/622195
dc.description.abstractEmerging evidence demonstrates that radiotherapy induces immunogenic death on tumor cells that emit immunostimulating signals resulting in tumor-specific immune responses. However, the impact of tumor features and microenvironmental factors on the efficacy of radiation-induced immunity remains to be elucidated. Herein, we use a calibrated model of tumor-effector cell interactions to investigate the potential benefits and immunological consequences of radiotherapy. Simulations analysis suggests that radiotherapy success depends on the functional tumor vascularity extent and reveals that the pre-treatment tumor size is not a consistent determinant of treatment outcomes. The one-size-fits-all approach of conventionally fractionated radiotherapy is predicted to result in some overtreated patients. In addition, model simulations also suggest that an arbitrary increase in treatment duration does not necessarily result in better tumor control. This study highlights the potential benefits of tumor-immune ecosystem profiling during treatment planning to better harness the immunogenic potential of radiotherapy.en_US
dc.language.isoenen_US
dc.publisherElsevier/Cell Pressen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBioinformaticsen_US
dc.subjectCanceren_US
dc.subjectMathematical Biosciencesen_US
dc.titleOn the Immunological Consequences of Conventionally Fractionated Radiotherapy.en_US
dc.typeArticleen_US
dc.contributor.departmentBRICS, Braunschweiger Zentrum für Systembiologie, Rebenring 56,38106 Braunschweig, Germany.en_US
dc.identifier.journaliScienceen_US
refterms.dateFOA2020-03-10T13:31:57Z
dc.source.journaltitleiScience


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Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International