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dc.contributor.authorMacabeo, Allan Patrick G
dc.contributor.authorPilapil, Luis Agustin E
dc.contributor.authorGarcia, Katherine Yasmin M
dc.contributor.authorQuimque, Mark Tristan J
dc.contributor.authorPhukhamsakda, Chayanard
dc.contributor.authorCruz, Allaine Jean C
dc.contributor.authorHyde, Kevin D
dc.contributor.authorStadler, Marc
dc.date.accessioned2020-03-12T11:30:07Z
dc.date.available2020-03-12T11:30:07Z
dc.date.issued2020-02-20
dc.identifier.citationMolecules. 2020 Feb 20;25(4). pii: molecules25040965. doi: 10.3390/molecules25040965.en_US
dc.identifier.issn1420-3049
dc.identifier.pmid32093426
dc.identifier.doi10.3390/molecules25040965
dc.identifier.urihttp://hdl.handle.net/10033/622202
dc.description.abstractThe alpha-glucosidase- and lipase-inhibitory activities of three phenalenones (1-3) and one phenylpropanoid (4) from the ethyl acetate extracts of a Pseudolophiosptoma sp. are described. They represent the first secondary metabolites reported from the genus Pseudolophiostoma. Scleroderolide (1) and sclerodione (2) exhibited potent α-glucosidase- and porcine-lipase-inhibitory activity during primary screening, with better IC50 values compared to the positive controls, N-deoxynojirimycin and orlistat. In silico techniques were employed to validate the probable biological targets and elucidate the mechanism of actions of phenalenones 1 and 2. Both compounds exhibited strong binding affinities to both alpha-glucosidase and porcine lipase through H-bonding and π-π interactions. Interestingly, favorable in silico ADME (absorption, distribution, metabolism, and excretion) properties such as gastrointestinal absorption were also predicted using software.en_US
dc.publisherMDPIen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectDothideomycetesen_US
dc.subjectPseudolophiostoma sp.en_US
dc.subjectanti-lipaseen_US
dc.subjectanti-α-glucosidaseen_US
dc.subjectmolecular dockingen_US
dc.subjectphenalenonesen_US
dc.titleAlpha-Glucosidase- and Lipase-Inhibitory Phenalenones from a New Species of Originating from Thailand.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalMoleculesen_US
refterms.dateFOA2020-03-12T11:30:08Z
dc.source.journaltitleMolecules (Basel, Switzerland)


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