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dc.contributor.authorSchimmel, Katharina
dc.contributor.authorJung, Mira
dc.contributor.authorFoinquinos, Ariana
dc.contributor.authorJosé, Gorka San
dc.contributor.authorBeaumont, Javier
dc.contributor.authorBock, Katharina
dc.contributor.authorGrote-Levi, Lea
dc.contributor.authorXiao, Ke
dc.contributor.authorBär, Christian
dc.contributor.authorPfanne, Angelika
dc.contributor.authorJust, Annette
dc.contributor.authorZimmer, Karina
dc.contributor.authorNgoy, Soeun
dc.contributor.authorLópez, Begoña
dc.contributor.authorRavassa, Susana
dc.contributor.authorSamolovac, Sabine
dc.contributor.authorJanssen-Peters, Heike
dc.contributor.authorRemke, Janet
dc.contributor.authorScherf, Kristian
dc.contributor.authorDangwal, Seema
dc.contributor.authorPiccoli, Maria-Teresa
dc.contributor.authorKleemiss, Felix
dc.contributor.authorKreutzer, Fabian Philipp
dc.contributor.authorKenneweg, Franziska
dc.contributor.authorLeonardy, Julia
dc.contributor.authorHobuß, Lisa
dc.contributor.authorSanter, Laura
dc.contributor.authorDo, Quoc-Tuan
dc.contributor.authorGeffers, Robert
dc.contributor.authorBraesen, Jan Hinrich
dc.contributor.authorSchmitz, Jessica
dc.contributor.authorBrandenberger, Christina
dc.contributor.authorMüller, Dominik N
dc.contributor.authorWilck, Nicola
dc.contributor.authorKaever, Volkhard
dc.contributor.authorBähre, Heike
dc.contributor.authorBatkai, Sandor
dc.contributor.authorFiedler, Jan
dc.contributor.authorAlexander, Kevin M
dc.contributor.authorWertheim, Bradley M
dc.contributor.authorFisch, Sudeshna
dc.contributor.authorLiao, Ronglih
dc.contributor.authorDiez, Javier
dc.contributor.authorGonzález, Arantxa
dc.contributor.authorThum, Thomas
dc.date.accessioned2020-03-17T13:50:45Z
dc.date.available2020-03-17T13:50:45Z
dc.date.issued2020-01-17
dc.identifier.citationCirculation. 2020 Mar 3;141(9):751-767. doi: 10.1161/CIRCULATIONAHA.119.042559. Epub 2020 Jan 17.en_US
dc.identifier.pmid31948273
dc.identifier.doi10.1161/CIRCULATIONAHA.119.042559
dc.identifier.urihttp://hdl.handle.net/10033/622209
dc.description.abstractHigh-throughput natural compound library screening identified 15 substances with antiproliferative effects in human cardiac fibroblasts. Using multiple in vitro fibrosis assays and stringent selection algorithms, we identified the steroid bufalin (from Chinese toad venom) and the alkaloid lycorine (from Amaryllidaceae species) to be effective antifibrotic molecules both in vitro and in vivo, leading to improvement in diastolic function in 2 hypertension-dependent rodent models of cardiac fibrosis. Administration at effective doses did not change plasma damage markers or the morphology of kidney and liver, providing the first toxicological safety data. Using next-generation sequencing, we identified the conserved microRNA 671-5p and downstream the antifibrotic selenoprotein P1 as common effectors of the antifibrotic compounds.en_US
dc.language.isoenen_US
dc.publisherLippincott, Williams & Wilkinsen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectdiastoleen_US
dc.subjectfibrosisen_US
dc.subjecthypertensionen_US
dc.subjectmicroRNAsen_US
dc.titleNatural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction.en_US
dc.typeArticleen_US
dc.identifier.eissn1524-4539
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalCirculationen_US
dc.source.volume141
dc.source.issue9
dc.source.beginpage751
dc.source.endpage767
refterms.dateFOA2020-03-17T13:50:47Z
atmire.accessrights
dc.source.journaltitleCirculation
dc.source.countryUnited States


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