One Step Ahead: Herpesviruses Light the Way to Understanding Interferon-Stimulated Genes (ISGs).
Name:
Gonzales-Perez et al.pdf
Size:
958.5Kb
Format:
PDF
Description:
Open Access publication
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Issue Date
2020-02-07
Metadata
Show full item recordAbstract
The host immune system is engaged in a constant battle with microorganisms, with the immediate detection of pathogenic invasion and subsequent signalling acting as crucial deterrents against the establishment of a successful infection. For this purpose, cells are equipped with a variety of sensors called pattern recognition receptors (PRR), which rapidly detect intruders leading to the expression of antiviral type I interferons (IFN). Type I IFN are crucial cytokines which exert their biological effects through the induction of hundreds of IFN-stimulated genes (ISGs). The expression profile of these ISGs varies depending on the virus. For a small subset of ISGs, their anti- or even proviral effects have been revealed, however, the vast majority are uncharacterised. The spotlight is now on herpesviruses, with their large coding capacity and long co-evolution with their hosts, as a key to understanding the impact of ISGs during viral infection. Studies are emerging which have identified multiple herpesviral antagonists specifically targeting ISGs, hinting at the significant role these proteins must play in host defence against viral infection, with the promise of more to come. In this review, we will discuss the current knowledge of the complex interplay between ISGs and human herpesviruses: the antiviral role of selected ISGs during herpesviral infections, how herpesviruses antagonise these ISGs and, in some cases, even exploit them to benefit viral infection.Citation
Front Microbiol. 2020 Feb 7;11:124. doi: 10.3389/fmicb.2020.00124. eCollection 2020.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
FrontiersJournal
Frontiers in microbiologyPubMed ID
32117146Type
ArticleOther
Language
enISSN
1664-302Xae974a485f413a2113503eed53cd6c53
10.3389/fmicb.2020.00124
Scopus Count
The following license files are associated with this item:
- Creative Commons
Related articles
- Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway.
- Authors: Raftery N, Stevenson NJ
- Issue date: 2017 Jul
- Mechanism of Interferon-Stimulated Gene Induction in HIV-1-Infected Macrophages.
- Authors: Nasr N, Alshehri AA, Wright TK, Shahid M, Heiner BM, Harman AN, Botting RA, Helbig KJ, Beard MR, Suzuki K, Kelleher AD, Hertzog P, Cunningham AL
- Issue date: 2017 Oct 15
- Innate Immune Responses to Herpesvirus Infection.
- Authors: O'Connor CM, Sen GC
- Issue date: 2021 Aug 18
- Coevolution pays off: Herpesviruses have the license to escape the DNA sensing pathway.
- Authors: Stempel M, Chan B, Brinkmann MM
- Issue date: 2019 Aug
- RIG-I is a key antiviral interferon-stimulated gene against hepatitis E virus regardless of interferon production.
- Authors: Xu L, Wang W, Li Y, Zhou X, Yin Y, Wang Y, de Man RA, van der Laan LJW, Huang F, Kamar N, Peppelenbosch MP, Pan Q
- Issue date: 2017 Jun