Haprolid Inhibits Tumor Growth of Hepatocellular Carcinoma through Rb/E2F and Akt/mTOR Inhibition.
dc.contributor.author | Xing, Jun | |
dc.contributor.author | Bhuria, Vikas | |
dc.contributor.author | Bui, Khac Cuong | |
dc.contributor.author | Nguyen, Mai Ly Thi | |
dc.contributor.author | Hu, Zexi | |
dc.contributor.author | Hsieh, Chih-Jen | |
dc.contributor.author | Wittstein, Kathrin | |
dc.contributor.author | Stadler, Marc | |
dc.contributor.author | Wilkens, Ludwig | |
dc.contributor.author | Li, Jun | |
dc.contributor.author | Kalesse, Markus | |
dc.contributor.author | Bozko, Przemyslaw | |
dc.contributor.author | Plentz, Ruben R | |
dc.date.accessioned | 2020-03-20T13:51:27Z | |
dc.date.available | 2020-03-20T13:51:27Z | |
dc.date.issued | 2020-03-06 | |
dc.identifier.citation | Cancers (Basel). 2020 Mar 6;12(3). pii: cancers12030615. doi: 10.3390/cancers12030615. | en_US |
dc.identifier.issn | 2072-6694 | |
dc.identifier.pmid | 32155915 | |
dc.identifier.doi | 10.3390/cancers12030615 | |
dc.identifier.uri | http://hdl.handle.net/10033/622214 | |
dc.description.abstract | The efficacy of haprolid was evaluated in human HCC cell lines (Huh-7, Hep3B and HepG2) and xenograft tumors (NMRI-Foxn1nu mice with injection of Hep3B cells). Cytotoxic activity of haprolid was determined by the WST-1 and crystal violet assay. Wound healing, transwell and tumorsphere assays were performed to investigate migration and invasion of HCC cells. Apoptosis and cell-cycle distribution were measured by flow cytometry. The effects of haprolid on the Rb/E2F and Akt/mTOR pathway were examined by immunoblotting and immunohistochemistry. | en_US |
dc.language.iso | en | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Akt/mTOR | en_US |
dc.subject | EMT | en_US |
dc.subject | HCC | en_US |
dc.subject | Rb/E2F | en_US |
dc.subject | apoptosis | en_US |
dc.subject | cell cycle | en_US |
dc.subject | haprolid | en_US |
dc.title | Haprolid Inhibits Tumor Growth of Hepatocellular Carcinoma through Rb/E2F and Akt/mTOR Inhibition. | en_US |
dc.type | Article | en_US |
dc.contributor.department | HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany. | en_US |
dc.identifier.journal | Cancers | en_US |
dc.source.volume | 12 | |
dc.source.issue | 3 | |
refterms.dateFOA | 2020-03-20T13:51:28Z | |
dc.source.journaltitle | Cancers | |
dc.source.country | Switzerland |