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dc.contributor.authorXing, Jun
dc.contributor.authorBhuria, Vikas
dc.contributor.authorBui, Khac Cuong
dc.contributor.authorNguyen, Mai Ly Thi
dc.contributor.authorHu, Zexi
dc.contributor.authorHsieh, Chih-Jen
dc.contributor.authorWittstein, Kathrin
dc.contributor.authorStadler, Marc
dc.contributor.authorWilkens, Ludwig
dc.contributor.authorLi, Jun
dc.contributor.authorKalesse, Markus
dc.contributor.authorBozko, Przemyslaw
dc.contributor.authorPlentz, Ruben R
dc.date.accessioned2020-03-20T13:51:27Z
dc.date.available2020-03-20T13:51:27Z
dc.date.issued2020-03-06
dc.identifier.citationCancers (Basel). 2020 Mar 6;12(3). pii: cancers12030615. doi: 10.3390/cancers12030615.en_US
dc.identifier.issn2072-6694
dc.identifier.pmid32155915
dc.identifier.doi10.3390/cancers12030615
dc.identifier.urihttp://hdl.handle.net/10033/622214
dc.description.abstractThe efficacy of haprolid was evaluated in human HCC cell lines (Huh-7, Hep3B and HepG2) and xenograft tumors (NMRI-Foxn1nu mice with injection of Hep3B cells). Cytotoxic activity of haprolid was determined by the WST-1 and crystal violet assay. Wound healing, transwell and tumorsphere assays were performed to investigate migration and invasion of HCC cells. Apoptosis and cell-cycle distribution were measured by flow cytometry. The effects of haprolid on the Rb/E2F and Akt/mTOR pathway were examined by immunoblotting and immunohistochemistry.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAkt/mTORen_US
dc.subjectEMTen_US
dc.subjectHCCen_US
dc.subjectRb/E2Fen_US
dc.subjectapoptosisen_US
dc.subjectcell cycleen_US
dc.subjecthaproliden_US
dc.titleHaprolid Inhibits Tumor Growth of Hepatocellular Carcinoma through Rb/E2F and Akt/mTOR Inhibition.en_US
dc.typeArticleen_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalCancersen_US
dc.source.volume12
dc.source.issue3
refterms.dateFOA2020-03-20T13:51:28Z
dc.source.journaltitleCancers
dc.source.countrySwitzerland


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