An Integrated Metagenome Catalog Reveals New Insights into the Murine Gut Microbiome.
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Authors
Lesker, Till RDurairaj, Abilash C
Gálvez, Eric J C
Lagkouvardos, Ilias
Baines, John F
Clavel, Thomas
Sczyrba, Alexander
McHardy, Alice C
Strowig, Till
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Show full item recordAbstract
The complexity of host-associated microbial ecosystems requires host-specific reference catalogs to survey the functions and diversity of these communities. We generate a comprehensive resource, the integrated mouse gut metagenome catalog (iMGMC), comprising 4.6 million unique genes and 660 metagenome-assembled genomes (MAGs), many (485 MAGs, 73%) of which are linked to reconstructed full-length 16S rRNA gene sequences. iMGMC enables unprecedented coverage and taxonomic resolution of the mouse gut microbiota; i.e., more than 92% of MAGs lack species-level representatives in public repositories (<95% ANI match). The integration of MAGs and 16S rRNA gene data allows more accurate prediction of functional profiles of communities than predictions based on 16S rRNA amplicons alone. Accompanying iMGMC, we provide a set of MAGs representing 1,296 gut bacteria obtained through complementary assembly strategies. We envision that integrated resources such as iMGMC, together with MAG collections, will enhance the resolution of numerous existing and future sequencing-based studies.Citation
Cell Rep. 2020 Mar 3;30(9):2909-2922.e6. doi: 10.1016/j.celrep.2020.02.036.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
Elsevier/Cell PressJournal
Cell reportsPubMed ID
32130896Type
ArticleLanguage
enEISSN
2211-1247ae974a485f413a2113503eed53cd6c53
10.1016/j.celrep.2020.02.036
Scopus Count
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- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
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