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dc.contributor.authorSanchez Alberti, Andrés
dc.contributor.authorBivona, Augusto E
dc.contributor.authorMatos, Marina N
dc.contributor.authorCerny, Natacha
dc.contributor.authorSchulze, Kai
dc.contributor.authorWeißmann, Sebastian
dc.contributor.authorEbensen, Thomas
dc.contributor.authorGonzález, Germán
dc.contributor.authorMorales, Celina
dc.contributor.authorCardoso, Alejandro C
dc.contributor.authorCazorla, Silvia I
dc.contributor.authorGuzmán, Carlos A
dc.contributor.authorMalchiodi, Emilio L
dc.date.accessioned2020-03-26T15:06:24Z
dc.date.available2020-03-26T15:06:24Z
dc.date.issued2020-02-21
dc.identifier.citationFront Immunol. 2020 Feb 21;11:128. doi: 10.3389/fimmu.2020.00128. eCollection 2020.en_US
dc.identifier.pmid32153562
dc.identifier.doi10.3389/fimmu.2020.00128
dc.identifier.urihttp://hdl.handle.net/10033/622219
dc.description.abstractThere are several unmet needs in modern immunology. Among them, vaccines against parasitic diseases and chronic infections lead. Trypanosoma cruzi, the causative agent of Chagas disease, is an excellent example of a silent parasitic invasion that affects millions of people worldwide due to its progression into the symptomatic chronic phase of infection. In search for novel vaccine candidates, we have previously introduced Traspain, an engineered trivalent immunogen that was designed to address some of the known mechanisms of T. cruzi immune evasion. Here, we analyzed its performance in different DNA prime/protein boost protocols and characterized the systemic immune response associated with diverse levels of protection. Formulations that include a STING agonist, like c-di-AMP in the boost doses, were able to prime a Th1/Th17 immune response. Moreover, comparison between them showed that vaccines that were able to prime polyfunctional cell-mediated immunity at the CD4 and CD8 compartment enhanced protection levels in the murine model. These findings contribute to a better knowledge of the desired vaccine-elicited immunity against T. cruzi and promote the definition of a vaccine correlate of protection against the infection.en_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAnti-Trypanosoma cruzi vaccineen_US
dc.subjectChagas diseaseen_US
dc.subjectT cell polyfunctionalityen_US
dc.subjectTraspainen_US
dc.subjectcell-mediated immunityen_US
dc.subjectcyclic-di-AMPen_US
dc.subjectneglected tropical diseaseen_US
dc.subjectprime-boost vaccineen_US
dc.titleMucosal Heterologous Prime/Boost Vaccination Induces Polyfunctional Systemic Immunity, Improving Protection Against .en_US
dc.typeArticleen_US
dc.identifier.eissn1664-3224
dc.contributor.departmentHZI, Helmholtz Zentrum für Infektionsforschung GmbH, Inhoffenstr.7, 38124 Braunschweig, Germany.en_US
dc.identifier.journalFrontiers in immunologyen_US
dc.source.volume11
dc.source.beginpage128
dc.source.endpage
refterms.dateFOA2020-03-26T15:06:25Z
dc.source.journaltitleFrontiers in immunology
dc.source.countrySwitzerland


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