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dc.contributor.authorNikolich-Žugich, Janko
dc.contributor.authorČicin-Šain, Luka
dc.contributor.authorCollins-McMillen, Donna
dc.contributor.authorJackson, Sarah
dc.contributor.authorOxenius, Annette
dc.contributor.authorSinclair, John
dc.contributor.authorSnyder, Christopher
dc.contributor.authorWills, Mark
dc.contributor.authorLemmermann, Niels
dc.date.accessioned2020-03-27T09:48:46Z
dc.date.available2020-03-27T09:48:46Z
dc.date.issued2020-03-11
dc.identifier.citationGeroscience. 2020 Mar 11. pii: 10.1007/s11357-020-00170-8. doi: 10.1007/s11357-020-00170-8.en_US
dc.identifier.pmid32162210
dc.identifier.doi10.1007/s11357-020-00170-8
dc.identifier.urihttp://hdl.handle.net/10033/622221
dc.description.abstractThe complexity of host-associated microbial ecosystems requires host-specific reference catalogs to survey the functions and diversity of these communities. We generate a comprehensive resource, the integrated mouse gut metagenome catalog (iMGMC), comprising 4.6 million unique genes and 660 metagenome-assembled genomes (MAGs), many (485 MAGs, 73%) of which are linked to reconstructed full-length 16S rRNA gene sequences. iMGMC enables unprecedented coverage and taxonomic resolution of the mouse gut microbiota; i.e., more than 92% of MAGs lack species-level representatives in public repositories (<95% ANI match). The integration of MAGs and 16S rRNA gene data allows more accurate prediction of functional profiles of communities than predictions based on 16S rRNA amplicons alone. Accompanying iMGMC, we provide a set of MAGs representing 1,296 gut bacteria obtained through complementary assembly strategies. We envision that integrated resources such as iMGMC, together with MAG collections, will enhance the resolution of numerous existing and future sequencing-based studies.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAgingen_US
dc.subjectCytomegalovirusen_US
dc.subjectImmune evasionen_US
dc.subjectImmunityen_US
dc.subjectLatencyen_US
dc.titleAdvances in cytomegalovirus (CMV) biology and its relationship to health, diseases, and aging.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn2509-2723
dc.identifier.journalGeroScienceen_US
refterms.dateFOA2020-03-27T09:48:47Z
dc.source.journaltitleGeroScience
dc.source.countrySwitzerland


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