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dc.contributor.authorZisopoulou, Stavroula A.
dc.contributor.authorBousis, Spyridon
dc.contributor.authorHaupenthal, Jörg
dc.contributor.authorHerrmann, Jennifer
dc.contributor.authorMüller, Rolf
dc.contributor.authorHirsch, Anna K.H.
dc.contributor.authorKomiotis, Dimitri
dc.contributor.authorGallos, John K.
dc.contributor.authorStathakis, Christos I.
dc.date.accessioned2020-04-14T11:13:51Z
dc.date.available2020-04-14T11:13:51Z
dc.date.issued2020-03-17
dc.identifier.issn09365214
dc.identifier.doi10.1055/s-0039-1690772
dc.identifier.urihttp://hdl.handle.net/10033/622227
dc.description.abstractA library of novel 2-substituted derivatives of the antibiotic natural product pentenomycin I is presented. The new collection of analogues is divided in two main classes, 2-alkynyl- and 2-aryl- derivatives, which are accessed by the appropriate type of palladium-catalyzed cross-coupling reaction of the 2-iodo-protected pentenomycin I with suitable nucleophiles. The new derivatives were tested for their activity against certain types of bacteria and one of them, compound 8h, was found to exhibit significant inhibitory activity against several Gram-positive bacteria but also displayed cytotoxic activity against eukaryotic cell lines.en_US
dc.description.sponsorshipEuropean Research Councilen_US
dc.language.isoenen_US
dc.publisherThiemeen_US
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/665250en_US
dc.rightsopenAccessen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subject(-)-pentenomycinen_US
dc.subjectantimicrobial agentsen_US
dc.subjectGram-positive bacteriaen_US
dc.subjectSonogashiraen_US
dc.subjectSuzukien_US
dc.titleSynthesis and Biological Evaluation of Novel 2-Substituted ­Analogues of (-)-Pentenomycin ien_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn14372096
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalSynletten_US
dc.identifier.eid2-s2.0-85081540129
dc.identifier.scopusidSCOPUS_ID:85081540129
dc.source.volume31
dc.source.issue5
dc.source.beginpage475
dc.source.endpage481
refterms.dateFOA2020-01-02T00:00:00Z
dc.source.journaltitleSynlett


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