Show simple item record

dc.contributor.authorMulwa, Lucky S.
dc.contributor.authorJansen, Rolf
dc.contributor.authorPraditya, Dimas F.
dc.contributor.authorMohr, Kathrin I.
dc.contributor.authorOkanya, Patrick W.
dc.contributor.authorWink, Joachim
dc.contributor.authorSteinmann, Eike
dc.contributor.authorStadler, Marc
dc.date.accessioned2020-05-15T13:59:30Z
dc.date.available2020-05-15T13:59:30Z
dc.date.issued2018-06-26
dc.identifier.citationBeilstein J Org Chem. 2018 Jun 26;14:1554-1562. doi: 10.3762/bjoc.14.132. eCollection 2018.en_US
dc.identifier.pmid30013682
dc.identifier.doi10.3762/bjoc.14.132
dc.identifier.urihttp://hdl.handle.net/10033/622262
dc.description.abstractLanyamycin (1/2), a secondary metabolite occurring as two epimers, was isolated from the myxobacterium Sorangium cellulosum, strain Soce 481. The structures of both epimers were elucidated from HRESIMS and 1D and 2D NMR data and the relative configuration of their macrolactone ring was assigned based on NOE and vicinal 1H NMR coupling constants and by calculation of a 3D model. Lanyamycin inhibited HCV infection into mammalian liver cells with an IC50 value of 11.8 µM, and exhibited a moderate cytotoxic activity against the mouse fibroblast cell line L929 and the human nasopharyngeal cell line KB3 with IC50 values of 3.1 and 1.5 μM, respectively, and also suppressed the growth of the Gram-positive bacterium Micrococcus luteus.en_US
dc.description.sponsorshipDeutscher Akademischer Austauschdiensten_US
dc.language.isoenen_US
dc.publisherBeilstein-Instituten_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectAntimicrobialen_US
dc.subjectHCVen_US
dc.subjectLanyamycinen_US
dc.subjectMacrolideen_US
dc.subjectSorangium cellulosumen_US
dc.titleLanyamycin, a macrolide antibiotic from Sorangium cellulosum, strain Soce 481 (Myxobacteria)en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn18605397
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalBeilstein Journal of Organic Chemistryen_US
dc.identifier.eid2-s2.0-85049412805
dc.identifier.scopusidSCOPUS_ID:85049412805
dc.source.volume14
dc.source.beginpage1554
dc.source.endpage1562
refterms.dateFOA2020-05-15T13:59:31Z
dc.source.journaltitleBeilstein Journal of Organic Chemistry


Files in this item

Thumbnail
Name:
Mulwa et al.pdf
Size:
732.3Kb
Format:
PDF
Description:
Open Access publication

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International