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dc.contributor.authorVogel, Jörg
dc.date.accessioned2020-05-27T10:05:35Z
dc.date.available2020-05-27T10:05:35Z
dc.date.issued2020-03-17
dc.identifier.citationMol Microbiol. 2020;113(3):550‐559. doi:10.1111/mmi.14476.en_US
dc.identifier.pmid32185839
dc.identifier.doi10.1111/mmi.14476
dc.identifier.urihttp://hdl.handle.net/10033/622275
dc.description.abstractOur body is colonized by a vast array of bacteria the sum of which forms our microbiota. The gut alone harbors >1,000 bacterial species. An understanding of their individual or synergistic contributions to human health and disease demands means to interfere with their functions on the species level. Most of the currently available antibiotics are broad-spectrum, thus too unspecific for a selective depletion of a single species of interest from the microbiota. Programmable RNA antibiotics in the form of short antisense oligonucleotides (ASOs) promise to achieve precision manipulation of bacterial communities. These ASOs are coupled to small peptides that carry them inside the bacteria to silence mRNAs of essential genes, for example, to target antibiotic-resistant pathogens as an alternative to standard antibiotics. There is already proof-of-principle with diverse bacteria, but many open questions remain with respect to true species specificity, potential off-targeting, choice of peptides for delivery, bacterial resistance mechanisms and the host response. While there is unlikely a one-fits-all solution for all microbiome species, I will discuss how recent progress in bacterial RNA biology may help to accelerate the development of programmable RNA antibiotics for microbiome editing and other applications.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectRNA-seqen_US
dc.subjectantibioticen_US
dc.subjectmicrobiomeen_US
dc.subjectsmall RNAen_US
dc.titleAn RNA biology perspective on species-specific programmable RNA antibiotics.en_US
dc.typeReviewen_US
dc.typeOtheren_US
dc.identifier.eissn1365-2958
dc.contributor.departmentHIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.en_US
dc.identifier.journalMolecular microbiologyen_US
dc.source.volume113
dc.source.issue3
dc.source.beginpage550
dc.source.endpage559
refterms.dateFOA2020-05-27T10:05:36Z
dc.source.journaltitleMolecular microbiology
dc.source.countryEngland


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