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dc.contributor.authorHosseini, Shirin
dc.contributor.authorMichaelsen-Preusse, Kristin
dc.contributor.authorGrigoryan, Gayane
dc.contributor.authorChhatbar, Chintan
dc.contributor.authorKalinke, Ulrich
dc.contributor.authorKorte, Martin
dc.date.accessioned2020-06-09T09:03:41Z
dc.date.available2020-06-09T09:03:41Z
dc.identifier.citationCell Rep. 2020;31(7):107666. doi:10.1016/j.celrep.2020.107666.en_US
dc.identifier.pmid32433975
dc.identifier.doi10.1016/j.celrep.2020.107666
dc.identifier.urihttp://hdl.handle.net/10033/622285
dc.description.abstractType I interferon receptor (IFNAR) signaling is a hallmark of viral control and host protection. Here, we show that, in the hippocampus of healthy IFNAR-deficient mice, synapse number and synaptic plasticity, as well as spatial learning, are impaired. This is also the case for IFN-β-deficient animals. Moreover, antibody-mediated IFNAR blocking acutely interferes with neuronal plasticity, whereas a low-dose application of IFN-β has a positive effect on dendritic spine structure. Interfering with IFNAR signaling in different cell types shows a role for cognitive function and synaptic plasticity specifically mediated by astrocytes. Intriguingly, levels of the astrocytic glutamate-aspartate transporter (GLAST) are reduced significantly upon IFN-β treatment and increase following inhibition of IFNAR signaling. These results indicate that, besides the prominent role for host defense, IFNAR is important for synaptic plasticity as well as cognitive function. Astrocytes are at the center stage of this so-far-unknown signaling cascade.en_US
dc.language.isoenen_US
dc.publisherElsevier (Cell Press)en_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleType I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS.en_US
dc.typeArticleen_US
dc.identifier.eissn2211-1247
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalCell reportsen_US
dc.source.volume31
dc.source.issue7
dc.source.beginpage107666
dc.source.endpage
refterms.dateFOA2020-06-09T09:03:41Z
dc.source.journaltitleCell reports
dc.source.countryUnited States


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