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dc.contributor.authorMohr, Kathrin I
dc.date.accessioned2020-06-11T11:47:12Z
dc.date.available2020-06-11T11:47:12Z
dc.date.issued2018-08-11
dc.identifier.citationMicroorganisms. 2018;6(3):84. Published 2018 Aug 11. doi:10.3390/microorganisms6030084.en_US
dc.identifier.issn2076-2607
dc.identifier.pmid30103481
dc.identifier.doi10.3390/microorganisms6030084
dc.identifier.urihttp://hdl.handle.net/10033/622295
dc.description.abstractThe discovery of new antibiotics is mandatory with regard to the increasing number of resistant pathogens. One approach is the search for new antibiotic producers in nature. Among actinomycetes, Bacillus species, and fungi, myxobacteria have been a rich source for bioactive secondary metabolites for decades. To date, about 600 substances could be described, many of them with antibacterial, antifungal, or cytostatic activity. But, recent cultivation-independent studies on marine, terrestrial, or uncommon habitats unequivocally demonstrate that the number of uncultured myxobacteria is much higher than would be expected from the number of cultivated strains. Although several highly promising myxobacterial taxa have been identified recently, this so-called Great Plate Count Anomaly must be overcome to get broader access to new secondary metabolite producers. In the last years it turned out that especially new species, genera, and families of myxobacteria are promising sources for new bioactive metabolites. Therefore, the cultivation of the hitherto uncultivable ones is our biggest challenge.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectdiversityen_US
dc.subjectmyxobacteriaen_US
dc.subjectnew antibioticsen_US
dc.subjectsecondary metabolitesen_US
dc.subjectuncultureden_US
dc.titleDiversity of Myxobacteria-We Only See the Tip of the Iceberg.en_US
dc.typeReviewen_US
dc.typeOtheren_US
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalMicroorganismsen_US
dc.source.volume6
dc.source.issue3
refterms.dateFOA2020-06-11T11:47:13Z
dc.source.journaltitleMicroorganisms
dc.source.countrySwitzerland


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