Type A viral hepatitis: A summary and update on the molecular virology, epidemiology, pathogenesis and prevention.
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Issue Date
2017-09-05
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Show full item recordAbstract
Although epidemic jaundice was well known to physicians of antiquity, it is only in recent years that medical science has begun to unravel the origins of hepatitis A virus (HAV) and the unique pathobiology underlying acute hepatitis A in humans. Improvements in sanitation and the successful development of highly efficacious vaccines have markedly reduced the worldwide prevalence and incidence of this enterically-transmitted infection over the past quarter century, yet the virus persists in vulnerable populations and remains a common cause of food-borne disease outbreaks in economically-advantaged societies. Reductions in the prevalence of HAV have led to increases in the median age at which infection occurs, often resulting in more severe disease in affected persons and paradoxical increases in disease burden in some developing nations. Here, we summarize recent advances in the molecular virology of HAV, an atypical member of the Picornaviridae family, survey what is known of the pathogenesis of hepatitis A in humans and the host-pathogen interactions that typify the infection, and review medical and public health aspects of immunisation and disease prevention.Citation
J Hepatol. 2017;S0168-8278(17)32278-X. doi:10.1016/j.jhep.2017.08.034.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
ElsevierJournal
Journal of hepatologyPubMed ID
28887164Type
ReviewOther
Language
enEISSN
1600-0641ae974a485f413a2113503eed53cd6c53
10.1016/j.jhep.2017.08.034
Scopus Count
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- Creative Commons
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