Show simple item record

dc.contributor.authorRenzi, Daniele Fernanda
dc.contributor.authorde Almeida Campos, Laís
dc.contributor.authorMiranda, Eduardo Hösel
dc.contributor.authorMainardes, Rubiana Mara
dc.contributor.authorAbraham, Wolf-Rainer
dc.contributor.authorGrigoletto, Diana Fortkamp
dc.contributor.authorKhalil, Najeh Maissar
dc.date.accessioned2020-06-19T11:07:32Z
dc.date.available2020-06-19T11:07:32Z
dc.date.issued2020-03-30
dc.identifier.citationCurr Med Chem. 2020;10.2174/0929867327666200330143338. doi:10.2174/0929867327666200330143338.en_US
dc.identifier.pmid32223729
dc.identifier.doi10.2174/0929867327666200330143338
dc.identifier.urihttp://hdl.handle.net/10033/622304
dc.description.abstractThe Fungal infections are diseases that are considered neglected although their infection rates have increased worldwide in the last decades. Thus, since the antifungal arsenal is restricted and many strains have shown resistance new therapeutic alternatives are necessary. Nanoparticles are considered important alternatives to promote drug delivery. In this sense, the objective of the present study was to evaluate the contributions of newly developed nanoparticles to the treatment of fungal infections. Studies have shown that nanoparticles generally improve the biopharmaceutical and pharmacokinetic characteristics of antifungals, which is reflected in a greater pharmacodynamic potential and lower toxicity, as well as the possibility of prolonged action. It also offers the proposition of new routes of administration. Nanotechnology is known to contribute to a new drug delivery system, not only for the control of infectious diseases, but for various other diseases as well. In recent years, several studies have emphasized its application in infectious diseases, presenting better alternatives for the treatment of fungal infections.en_US
dc.language.isoenen_US
dc.publisherBentham Science Publisheren_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectazolesen_US
dc.subjectechinocandinsen_US
dc.subjectfungal infectionen_US
dc.subjectnanotechnologyen_US
dc.subjectpolyenes.en_US
dc.titleNanoparticles as A Tool for Broadening Antifungal Activities.en_US
dc.typeArticleen_US
dc.identifier.eissn1875-533X
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalCurrent medicinal chemistryen_US
dc.source.journaltitleCurrent medicinal chemistry
dc.source.countryUnited Arab Emirates


Files in this item

Thumbnail
Name:
Renzi et al.pdf
Embargo:
2021-03-30
Size:
1.176Mb
Format:
PDF
Description:
original manuscript

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International