Human microbial metabolite mimicry as a strategy to expand the chemical space of potential drugs.
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Issue Date
2020-06-17
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Show full item recordAbstract
he concept of small-molecule mimicry even of weak microbial metabolites present in rodents and humans, as a means to expand drug repertoires, is new. Hitherto, there are few proof-of-concept papers demonstrating utility of this concept. More recently, papers demonstrating mimicry of intestinal microbial metabolites could expand the drug repertoire for diseases such as inflammatory bowel disease (IBD). We opine that, as more functional metabolite-receptor pairings are discovered, small-molecule metabolite mimicry could be a significant effort in drug discovery.Citation
Drug Discov Today. 2020;S1359-6446(20)30233-6. doi:10.1016/j.drudis.2020.06.007.Affiliation
HIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.Publisher
ElsevierJournal
Drug discovery todayPubMed ID
32562605Type
ArticleLanguage
enEISSN
1878-5832ae974a485f413a2113503eed53cd6c53
10.1016/j.drudis.2020.06.007
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