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dc.contributor.authorLi, Hao
dc.contributor.authorRanhotra, Harmit S
dc.contributor.authorMani, Sridhar
dc.contributor.authorDvořák, Zdeněk
dc.contributor.authorSokol, Harry
dc.contributor.authorMüller, Rolf
dc.date.accessioned2020-07-14T13:33:09Z
dc.date.available2020-07-14T13:33:09Z
dc.date.issued2020-06-17
dc.identifier.citationDrug Discov Today. 2020;S1359-6446(20)30233-6. doi:10.1016/j.drudis.2020.06.007.en_US
dc.identifier.pmid32562605
dc.identifier.doi10.1016/j.drudis.2020.06.007
dc.identifier.urihttp://hdl.handle.net/10033/622349
dc.description.abstracthe concept of small-molecule mimicry even of weak microbial metabolites present in rodents and humans, as a means to expand drug repertoires, is new. Hitherto, there are few proof-of-concept papers demonstrating utility of this concept. More recently, papers demonstrating mimicry of intestinal microbial metabolites could expand the drug repertoire for diseases such as inflammatory bowel disease (IBD). We opine that, as more functional metabolite-receptor pairings are discovered, small-molecule metabolite mimicry could be a significant effort in drug discovery.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleHuman microbial metabolite mimicry as a strategy to expand the chemical space of potential drugs.en_US
dc.typeArticleen_US
dc.identifier.eissn1878-5832
dc.contributor.departmentHIRI, Helmholtz-Institut für RNA-basierte Infektionsforschung, Josef-Shneider Strasse 2, 97080 Würzburg, Germany.en_US
dc.identifier.journalDrug discovery todayen_US
dc.source.journaltitleDrug discovery today
dc.source.countryUnited States
dc.source.countryEngland


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