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AbstractDendritic spines are tiny membrane specialization forming the postsynaptic part of most excitatory synapses. They have been suggested to play a crucial role in regulating synaptic transmission during development and in adult learning processes. Changes in their number, size, and shape are correlated with processes of structural synaptic plasticity and learning and memory and also with neurodegenerative diseases, when spines are lost. Thus, their alterations can correlate with neuronal homeostasis, but also with dysfunction in several neurological disorders characterized by cognitive impairment. Therefore, it is important to understand how different stages in the life of a dendritic spine, including formation, maturation, and plasticity, are strictly regulated. In this context, brain-derived neurotrophic factor (BDNF), belonging to the NGF-neurotrophin family, is among the most intensively investigated molecule. This review would like to report the current knowledge regarding the role of BDNF in regulating dendritic spine number, structure, and plasticity concentrating especially on its signaling via its two often functionally antagonistic receptors, TrkB and p75NTR. In addition, we point out a series of open points in which, while the role of BDNF signaling is extremely likely conclusive, evidence is still missing.
CitationCell Tissue Res. 2020;10.1007/s00441-020-03226-5. doi:10.1007/s00441-020-03226-5.
AffiliationHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
JournalCell and tissue research
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- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International
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- Authors: Li M, Dai FR, Du XP, Yang QD, Zhang X, Chen Y
- Issue date: 2012 May 16
- The BDNF effects on dendritic spines of mature hippocampal neurons depend on neuronal activity.
- Authors: Kellner Y, Gödecke N, Dierkes T, Thieme N, Zagrebelsky M, Korte M
- Issue date: 2014
- Control of spine maturation and pruning through proBDNF synthesized and released in dendrites.
- Authors: Orefice LL, Shih CC, Xu H, Waterhouse EG, Xu B
- Issue date: 2016 Mar
- Autocrine BDNF-TrkB signalling within a single dendritic spine.
- Authors: Harward SC, Hedrick NG, Hall CE, Parra-Bueno P, Milner TA, Pan E, Laviv T, Hempstead BL, Yasuda R, McNamara JO
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- BDNF effects on dendritic spine morphology and hippocampal function.
- Authors: von Bohlen Und Halbach O, von Bohlen Und Halbach V
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