Show simple item record

dc.contributor.authorZagrebelsky, Marta
dc.contributor.authorTacke, Charlotte
dc.contributor.authorKorte, Martin
dc.date.accessioned2020-07-15T12:47:50Z
dc.date.available2020-07-15T12:47:50Z
dc.date.issued2020-06-14
dc.identifier.citationCell Tissue Res. 2020;10.1007/s00441-020-03226-5. doi:10.1007/s00441-020-03226-5.en_US
dc.identifier.pmid32537724
dc.identifier.doi10.1007/s00441-020-03226-5
dc.identifier.urihttp://hdl.handle.net/10033/622352
dc.description.abstractDendritic spines are tiny membrane specialization forming the postsynaptic part of most excitatory synapses. They have been suggested to play a crucial role in regulating synaptic transmission during development and in adult learning processes. Changes in their number, size, and shape are correlated with processes of structural synaptic plasticity and learning and memory and also with neurodegenerative diseases, when spines are lost. Thus, their alterations can correlate with neuronal homeostasis, but also with dysfunction in several neurological disorders characterized by cognitive impairment. Therefore, it is important to understand how different stages in the life of a dendritic spine, including formation, maturation, and plasticity, are strictly regulated. In this context, brain-derived neurotrophic factor (BDNF), belonging to the NGF-neurotrophin family, is among the most intensively investigated molecule. This review would like to report the current knowledge regarding the role of BDNF in regulating dendritic spine number, structure, and plasticity concentrating especially on its signaling via its two often functionally antagonistic receptors, TrkB and p75NTR. In addition, we point out a series of open points in which, while the role of BDNF signaling is extremely likely conclusive, evidence is still missing.en_US
dc.language.isoenen_US
dc.publisherSringer Natureen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBrain-derived neurotrophic factoren_US
dc.subjectDendritic spinesen_US
dc.subjectNeurotrophinen_US
dc.subjectTrkBen_US
dc.subjectp75NTRen_US
dc.titleBDNF signaling during the lifetime of dendritic spines.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn1432-0878
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalCell and tissue researchen_US
refterms.dateFOA2020-07-15T12:47:50Z
dc.source.journaltitleCell and tissue research
dc.source.countryGermany


Files in this item

Thumbnail
Name:
Zagrebelsky, Tacke and Korte.pdf
Size:
806.2Kb
Format:
PDF
Description:
Open Access publication

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International