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dc.contributor.authorRieg, Siegbert
dc.contributor.authorBechet, Lena
dc.contributor.authorNaujoks, Kai
dc.contributor.authorHromek, Julia
dc.contributor.authorLange, Berit
dc.contributor.authorJuzek-Küpper, Marc-Fabian
dc.contributor.authorStete, Katarina
dc.contributor.authorMüller, Matthias C
dc.contributor.authorJost, Insa
dc.contributor.authorKern, Winfried V
dc.contributor.authorTheilacker, Christian
dc.date.accessioned2020-07-29T09:59:10Z
dc.date.available2020-07-29T09:59:10Z
dc.date.issued2020-02-13
dc.identifier.citationOpen Forum Infect Dis. 2020;7(3):ofaa050. Published 2020 Feb 13. doi:10.1093/ofid/ofaa050.en_US
dc.identifier.issn2328-8957
dc.identifier.pmid32158777
dc.identifier.doi10.1093/ofid/ofaa050
dc.identifier.urihttp://hdl.handle.net/10033/622370
dc.description.abstractA total of 459 asplenic patients were enrolled, and 426 patients were followed prospectively over a median period of 2.9 years. Pneumococcal vaccine uptake within 3 months of splenectomy or first diagnosis of asplenia was 27% vs 71% among delayed study entry and early study entry patients, respectively (P < .001). Forty-four episodes of severe sepsis or septic shock occurred in study patients: 22 after study entry and 22 before study entry. Streptococcus pneumoniae was more frequent among sepsis episodes that occurred before study entry (8/22) than after study entry (1/22 episodes). For episodes occurring after study entry, only a higher Charlson comorbidity index score was significantly associated with severe sepsis/septic shock postsplenectomy.en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectaspleniaen_US
dc.subjectpostsplenectomy sepsisen_US
dc.subjectvaccinationen_US
dc.titleA Single-Center Prospective Cohort Study on Postsplenectomy Sepsis and its Prevention.en_US
dc.typeArticleen_US
dc.identifier.journalOpen forum infectious diseasesen_US
dc.source.volume7
dc.source.issue3
dc.source.beginpageofaa050
dc.source.endpage
refterms.dateFOA2020-07-29T09:59:10Z
dc.source.journaltitleOpen forum infectious diseases
dc.source.countryUnited States


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