Show simple item record

dc.contributor.authorSmoczek, Margarethe
dc.contributor.authorVital, Marius
dc.contributor.authorWedekind, Dirk
dc.contributor.authorBasic, Marijana
dc.contributor.authorZschemisch, Nils-Holger
dc.contributor.authorPieper, Dietmar H
dc.contributor.authorSiebert, Anja
dc.contributor.authorBleich, Andre
dc.contributor.authorBuettner, Manuela
dc.date.accessioned2020-08-07T12:48:22Z
dc.date.available2020-08-07T12:48:22Z
dc.date.issued2020-04-09
dc.identifier.citationSci Rep. 2020;10(1):6118. Published 2020 Apr 9. doi:10.1038/s41598-020-63340-w.en_US
dc.identifier.pmid32273571
dc.identifier.doi10.1038/s41598-020-63340-w
dc.identifier.urihttp://hdl.handle.net/10033/622396
dc.description.abstractObesity has emerged as a major global health problem and is associated with various diseases, such as metabolic syndrome, type 2 diabetes mellitus, and cardiovascular diseases. The inbred C57BL/6 mouse strain is often used for various experimental investigations, such as metabolic research. However, over time, genetically distinguishable C57BL/6 substrains have evolved. The manifestation of genetic alterations has resulted in behavioral and metabolic differences. In this study, a comparison of diet-induced obesity in C57BL/6JHanZtm, C57BL/6NCrl and C57BL/6 J mice revealed several metabolic and immunological differences such as blood glucose level and cytokine expression, respectively, among these C57BL/6 substrains. For example, C57BL/6NCrl mice developed the most pronounced adiposity, whereas C57BL/6 J mice showed the highest impairment in glucose tolerance. Moreover, our results indicated that the immunological phenotype depends on the intestinal microbiota, as the cell subset composition of the colon was similar in obese ex-GF B6NRjB6JHanZtm and obese B6JHanZtm mice. Phenotypic differences between C57BL/6 substrains are caused by a complex combination of genetic and microbial alterations. Therefore, in performing metabolic research, considering substrain-specific characteristics, which can influence the course of study, is important. Moreover, for unbiased comparison of data, the entire strain name should be shared with the scientific community.en_US
dc.language.isoenen_US
dc.publisherNPGen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleA combination of genetics and microbiota influences the severity of the obesity phenotype in diet-induced obesity.en_US
dc.typeArticleen_US
dc.identifier.eissn2045-2322
dc.contributor.departmentHIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.en_US
dc.identifier.journalScientific reportsen_US
dc.source.volume10
dc.source.issue1
dc.source.beginpage6118
dc.source.endpage
refterms.dateFOA2020-08-07T12:48:23Z
dc.source.journaltitleScientific reports
dc.source.countryEngland


Files in this item

Thumbnail
Name:
Smoczek et al.pdf
Size:
2.243Mb
Format:
PDF
Description:
Open Access publication

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International