Irreversible impact of chronic hepatitis C virus infection on human natural killer cell diversity.
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Issue Date
2018-07-25
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Show full item recordAbstract
Diversity is crucial for the immune system to efficiently combat infections. Natural killer (NK) cells are innate cytotoxic lymphocytes that contribute to the control of viral infections. NK cells were for long thought to be a homogeneous population of cells. However, recent work has instead revealed NK cells to represent a highly diverse population of immune cells where a vast number of subpopulations with distinct characteristics exist across tissues. However, the degree to which a chronic viral infection affects NK cell diversity remains elusive. Hepatitis C virus (HCV) is effective in establishing chronic infection in humans. During the last years, new direct-acting antiviral drugs (DAA) have revolutionized treatment of chronic hepatitis C, enabling rapid cure in the majority of patients. This allows us to study the influence of a chronic viral infection and its subsequent elimination on the NK cell compartment with a focus on NK cell diversity. In our recent study (Nat Commun, 9:2275), we show that chronic HCV infection irreversibly impacts human NK cell repertoire diversity.Citation
Cell Stress. 2018;2(8):216-218. Published 2018 Jul 25. doi:10.15698/cst2018.07.150.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
Shared Science orgJournal
Cell stressPubMed ID
31225489Type
ArticleOther
Language
enEISSN
2523-0204ae974a485f413a2113503eed53cd6c53
10.15698/cst2018.07.150
Scopus Count
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