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dc.contributor.authorStrunz, Benedikt
dc.contributor.authorHengst, Julia
dc.contributor.authorWedemeyer, Heiner
dc.contributor.authorBjörkström, Niklas K
dc.date.accessioned2020-08-11T08:21:15Z
dc.date.available2020-08-11T08:21:15Z
dc.date.issued2018-07-25
dc.identifier.citationCell Stress. 2018;2(8):216-218. Published 2018 Jul 25. doi:10.15698/cst2018.07.150.en_US
dc.identifier.pmid31225489
dc.identifier.doi10.15698/cst2018.07.150
dc.identifier.urihttp://hdl.handle.net/10033/622397
dc.description.abstractDiversity is crucial for the immune system to efficiently combat infections. Natural killer (NK) cells are innate cytotoxic lymphocytes that contribute to the control of viral infections. NK cells were for long thought to be a homogeneous population of cells. However, recent work has instead revealed NK cells to represent a highly diverse population of immune cells where a vast number of subpopulations with distinct characteristics exist across tissues. However, the degree to which a chronic viral infection affects NK cell diversity remains elusive. Hepatitis C virus (HCV) is effective in establishing chronic infection in humans. During the last years, new direct-acting antiviral drugs (DAA) have revolutionized treatment of chronic hepatitis C, enabling rapid cure in the majority of patients. This allows us to study the influence of a chronic viral infection and its subsequent elimination on the NK cell compartment with a focus on NK cell diversity. In our recent study (Nat Commun, 9:2275), we show that chronic HCV infection irreversibly impacts human NK cell repertoire diversity.en_US
dc.language.isoenen_US
dc.publisherShared Science orgen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectHepatitis C virus infectionen_US
dc.subjectdirect-acting antiviral therapyen_US
dc.subjectnatural killer cellsen_US
dc.titleIrreversible impact of chronic hepatitis C virus infection on human natural killer cell diversity.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn2523-0204
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalCell stressen_US
dc.source.volume2
dc.source.issue8
dc.source.beginpage216
dc.source.endpage218
refterms.dateFOA2020-08-11T08:21:15Z
dc.source.journaltitleCell stress
dc.source.countryAustria


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