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dc.contributor.authorBecker, C Guilherme
dc.contributor.authorBletz, Molly C
dc.contributor.authorGreenspan, Sasha E
dc.contributor.authorRodriguez, David
dc.contributor.authorLambertini, Carolina
dc.contributor.authorJenkinson, Thomas S
dc.contributor.authorGuimarães, Paulo R
dc.contributor.authorAssis, Ana Paula A
dc.contributor.authorGeffers, Robert
dc.contributor.authorJarek, Michael
dc.contributor.authorToledo, Luís Felipe
dc.contributor.authorVences, Miguel
dc.contributor.authorHaddad, Célio F B
dc.date.accessioned2020-08-18T11:45:06Z
dc.date.available2020-08-18T11:45:06Z
dc.date.issued2019-08-14
dc.identifier.citationProc Biol Sci. 2019;286(1908):20191114. doi:10.1098/rspb.2019.1114.en_US
dc.identifier.pmid31409249
dc.identifier.doi10.1098/rspb.2019.1114
dc.identifier.urihttp://hdl.handle.net/10033/622413
dc.description.abstractWildlife disease dynamics are strongly influenced by the structure of host communities and their symbiotic microbiota. Conspicuous amphibian declines associated with the waterborne fungal pathogen Batrachochytrium dendrobatidis (Bd) have been observed in aquatic-breeding frogs globally. However, less attention has been given to cryptic terrestrial-breeding amphibians that have also been declining in tropical regions. By experimentally manipulating multiple tropical amphibian assemblages harbouring natural microbial communities, we tested whether Bd spillover from naturally infected aquatic-breeding frogs could lead to Bd amplification and mortality in our focal terrestrial-breeding host: the pumpkin toadlet Brachycephalus pitanga. We also tested whether the strength of spillover could vary depending on skin bacterial transmission within host assemblages. Terrestrial-breeding toadlets acquired lethal spillover infections from neighbouring aquatic hosts and experienced dramatic but generally non-protective shifts in skin bacterial composition primarily attributable to their Bd infections. By contrast, aquatic-breeding amphibians maintained mild Bd infections and higher survival, with shifts in bacterial microbiomes that were unrelated to Bd infections. Our results indicate that Bd spillover from even mildly infected aquatic-breeding hosts may lead to dysbiosis and mortality in terrestrial-breeding species, underscoring the need to further investigate recent population declines of terrestrial-breeding amphibians in the tropics.en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Londonen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectBatrachochytrium dendrobatidisen_US
dc.subjectchytridiomycosisen_US
dc.subjectcommunity compositionen_US
dc.subjectdirect developmenten_US
dc.subjecthost microbiomeen_US
dc.titleLow-load pathogen spillover predicts shifts in skin microbiome and survival of a terrestrial-breeding amphibian.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn1471-2954
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalProceedings. Biological sciencesen_US
dc.source.volume286
dc.source.issue1908
dc.source.beginpage20191114
dc.source.endpage
refterms.dateFOA2020-08-18T11:45:07Z
dc.source.journaltitleProceedings. Biological sciences
dc.source.countryEngland


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