A network of trans-cortical capillaries as mainstay for blood circulation in long bones.
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Authors
Grüneboom, AnikaHawwari, Ibrahim
Weidner, Daniela
Culemann, Stephan
Müller, Sylvia
Henneberg, Sophie
Brenzel, Alexandra
Merz, Simon
Bornemann, Lea
Zec, Kristina
Wuelling, Manuela
Kling, Lasse
Hasenberg, Mike
Voortmann, Sylvia
Lang, Stefanie
Baum, Wolfgang
Ohs, Alexandra
Kraff, Oliver
Quick, Harald H
Jäger, Marcus
Landgraeber, Stefan
Dudda, Marcel
Danuser, Renzo
Stein, Jens V
Rohde, Manfred
Gelse, Kolja
Garbe, Annette I
Adamczyk, Alexandra
Westendorf, Astrid M
Hoffmann, Daniel
Christiansen, Silke
Engel, Daniel Robert
Vortkamp, Andrea
Krönke, Gerhard
Herrmann, Martin
Kamradt, Thomas
Schett, Georg
Hasenberg, Anja
Gunzer, Matthias
Issue Date
2019-01-21
Metadata
Show full item recordAbstract
Closed circulatory systems (CCS) underlie the function of vertebrate organs, but in long bones their structure is unclear, although they constitute the exit route for bone marrow (BM) leukocytes. To understand neutrophil emigration from BM, we studied the vascular system of murine long bones. Here we show that hundreds of capillaries originate in BM, cross murine cortical bone perpendicularly along the shaft and connect to the periosteal circulation. Structures similar to these trans-cortical-vessels (TCVs) also exist in human limb bones. TCVs express arterial or venous markers and transport neutrophils. Furthermore, over 80% arterial and 59% venous blood passes through TCVs. Genetic and drug-mediated modulation of osteoclast count and activity leads to substantial changes in TCV numbers. In a murine model of chronic arthritic bone inflammation, new TCVs develop within weeks. Our data indicate that TCVs are a central component of the CCS in long bones and may represent an important route for immune cell export from the BM.Citation
Nat Metab. 2019;1(2):236-250. doi:10.1038/s42255-018-0016-5.Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.Publisher
Nature publishing group(NPG)Journal
Nature metabolismPubMed ID
31620676Type
ArticleLanguage
enEISSN
2522-5812ae974a485f413a2113503eed53cd6c53
10.1038/s42255-018-0016-5
Scopus Count
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