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IL22BP Mediates the Anti-Tumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans.

dc.contributor.authorKempski, Jan
dc.contributor.authorGiannou, Anastasios D
dc.contributor.authorRiecken, Kristoffer
dc.contributor.authorZhao, Lilan
dc.contributor.authorSteglich, Babett
dc.contributor.authorLücke, Jöran
dc.contributor.authorGarcia-Perez, Laura
dc.contributor.authorKarstens, Karl-Frederick
dc.contributor.authorWöstemeier, Anna
dc.contributor.authorNawrocki, Mikolaj
dc.contributor.authorPelczar, Penelope
dc.contributor.authorWitkowski, Mario
dc.contributor.authorNilsson, Sven
dc.contributor.authorKonczalla, Leonie
dc.contributor.authorShiri, Ahmad Mustafa
dc.contributor.authorKempska, Joanna
dc.contributor.authorWahib, Ramez
dc.contributor.authorBrockmann, Leonie
dc.contributor.authorHuber, Philipp
dc.contributor.authorGnirck, Ann-Christin
dc.contributor.authorTurner, Jan-Eric
dc.contributor.authorZazara, Dimitra E
dc.contributor.authorArck, Petra C
dc.contributor.authorStein, Alexander
dc.contributor.authorSimon, Ronald
dc.contributor.authorDaubmann, Anne
dc.contributor.authorMeiners, Jan
dc.contributor.authorPerez, Daniel
dc.contributor.authorStrowig, Till
dc.contributor.authorKoni, Pandelakis
dc.contributor.authorKruglov, Andrey A
dc.contributor.authorSauter, Guido
dc.contributor.authorIzbicki, Jakob R
dc.contributor.authorGuse, Andreas H
dc.contributor.authorRoesch, Thomas
dc.contributor.authorLohse, Ansgar W
dc.contributor.authorFlavell, Richard A
dc.contributor.authorGagliani, Nicola
dc.contributor.authorHuber, Samuel
dc.date.accessioned2020-08-19T13:37:00Z
dc.date.available2020-08-19T13:37:00Z
dc.date.issued2020-06-18
dc.identifier.citationGastroenterology. 2020;S0016-5085(20)34833-2. doi:10.1053/j.gastro.2020.06.033.en_US
dc.identifier.pmid32585307
dc.identifier.doi10.1053/j.gastro.2020.06.033
dc.identifier.urihttp://hdl.handle.net/10033/622416
dc.description.abstractWe obtained tumor and non-tumor tissues from patients with colorectal cancer (CRC) and measured levels of cytokines by quantitative PCR, flow cytometry, and immunohistochemistry. We measured levels of Il22bp mRNA in colon tissues from wild-type, Tnf-/-, Lta-/-, and Ltb-/- mice. Mice were given azoxymethane and dextran sodium sulfate, to induce colitis and associated cancer, or intra-caecal injections of MC38 tumor cells. Some mice were given inhibitors of lymphotoxin beta receptor (LTBR). Intestine tissues were analyzed by single-cell sequencing to identify cell sources of lymphotoxin. We performed immunohistochemistry analysis of colon tissue microarrays from patients with CRC (1475 tissue cores, contained tumor and non-tumor tissues) and correlated levels of IL22BP with patient survival times.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/337251en_US
dc.rightsopenAccessen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectcytokine signalingen_US
dc.subjectimmune regulationen_US
dc.subjectinflammationen_US
dc.subjecttumor suppressoren_US
dc.titleIL22BP Mediates the Anti-Tumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans.en_US
dc.typeArticleen_US
dc.identifier.eissn1528-0012
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalGastroenterologyen_US
refterms.dateFOA2020-08-19T13:37:01Z
dc.source.journaltitleGastroenterology
dc.source.countryUnited States


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