Show simple item record

dc.contributor.authorTroeger, Christopher E
dc.contributor.authorGBD 2017 Influenza Collaborators
dc.date.accessioned2020-09-02T10:43:59Z
dc.date.available2020-09-02T10:43:59Z
dc.date.issued2018-12-12
dc.identifier.citationLancet Respir Med. 2019;7(1):69-89. doi:10.1016/S2213-2600(18)30496-X.en_US
dc.identifier.pmid30553848
dc.identifier.doi10.1016/S2213-2600(18)30496-X
dc.identifier.urihttp://hdl.handle.net/10033/622422
dc.description.abstractBackground: Although the burden of influenza is often discussed in the context of historical pandemics and the threat of future pandemics, every year a substantial burden of lower respiratory tract infections (LRTIs) and other respiratory conditions (like chronic obstructive pulmonary disease) are attributable to seasonal influenza. The Global Burden of Disease Study (GBD) 2017 is a systematic scientific effort to quantify the health loss associated with a comprehensive set of diseases and disabilities. In this Article, we focus on LRTIs that can be attributed to influenza. Methods: We modelled the LRTI incidence, hospitalisations, and mortality attributable to influenza for every country and selected subnational locations by age and year from 1990 to 2017 as part of GBD 2017. We used a counterfactual approach that first estimated the LRTI incidence, hospitalisations, and mortality and then attributed a fraction of those outcomes to influenza. Findings: Influenza LRTI was responsible for an estimated 145 000 (95% uncertainty interval [UI] 99 000-200 000) deaths among all ages in 2017. The influenza LRTI mortality rate was highest among adults older than 70 years (16·4 deaths per 100 000 [95% UI 11·6-21·9]), and the highest rate among all ages was in eastern Europe (5·2 per 100 000 population [95% UI 3·5-7·2]). We estimated that influenza LRTIs accounted for 9 459 000 (95% UI 3 709 000-22 935 000) hospitalisations due to LRTIs and 81 536 000 hospital days (24 330 000-259 851 000). We estimated that 11·5% (95% UI 10·0-12·9) of LRTI episodes were attributable to influenza, corresponding to 54 481 000 (38 465 000-73 864 000) episodes and 8 172 000 severe episodes (5 000 000-13 296 000). Interpretation: This comprehensive assessment of the burden of influenza LRTIs shows the substantial annual effect of influenza on global health. Although preparedness planning will be important for potential pandemics, health loss due to seasonal influenza LRTIs should not be overlooked, and vaccine use should be considered. Efforts to improve influenza prevention measures are needed.en_US
dc.description.sponsorshipBill & Melinda Gates Foundationen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.titleMortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn2213-2619
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalThe Lancet. Respiratory medicineen_US
dc.source.volume7
dc.source.issue1
dc.source.beginpage69
dc.source.endpage89
refterms.dateFOA2020-09-02T10:44:00Z
dc.source.journaltitleThe Lancet. Respiratory medicine
dc.source.countryEngland


Files in this item

Thumbnail
Name:
Publisher version
Thumbnail
Name:
Troeger et al.pdf
Size:
2.499Mb
Format:
PDF
Description:
Open Access article

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International