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dc.contributor.authorTungen, Jørn Eivind
dc.contributor.authorGerstmann, Lisa
dc.contributor.authorVik, Anders
dc.contributor.authorDe Matteis, Roberta
dc.contributor.authorColas, Romain Alexandre
dc.contributor.authorDalli, Jesmond
dc.contributor.authorChiang, Nan
dc.contributor.authorSerhan, Charles Nicholas
dc.contributor.authorKalesse, Markus
dc.contributor.authorHansen, Trond Vidar
dc.date.accessioned2020-09-28T11:34:51Z
dc.date.available2020-09-28T11:34:51Z
dc.date.issued2018-12-20
dc.identifier.citationChemistry. 2019 Jan 28;25(6):1476-1480. doi: 10.1002/chem.201806029. Epub 2018 Dec 20.en_US
dc.identifier.pmid30511787
dc.identifier.doi10.1002/chem.201806029
dc.identifier.urihttp://hdl.handle.net/10033/622487
dc.description.abstractNew drugs that can resolve inflammation without immunosuppressive effects are at the medicinal chemistry frontier. Pro-resolving endogenously formed small molecules, that is, the resolvins, are excellent candidates displaying such bioactions. The first total synthesis of the specialized pro-resolving mediator RvD1n-3 DPA has been achieved using the underutilized sp3 -sp3 Negishi cross coupling reaction and an alkyne hydrosilylation-protodesilylation protocol. Biological evaluations revealed that this novel mediator displays low nanomolar pro-resolving properties and potently activates the human DRV1/GPR32 receptor. As such, this endogenous natural product is a lead compound for the development of novel immunoresolvents.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relationinfo:eu-repo/grantAgreement/H2020/677542en_US
dc.rightsopenAccessen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectKarstedt's catalysten_US
dc.subjectnatural productsen_US
dc.subjectsp3-sp3 cross-couplingen_US
dc.subjectspecialized pro-resolving mediatorsen_US
dc.subjecttotal synthesisen_US
dc.titleResolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1.en_US
dc.typeArticleen_US
dc.identifier.eissn1521-3765
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalChemistry (Weinheim an der Bergstrasse, Germany)en_US
dc.source.volume25
dc.source.issue6
dc.source.beginpage1476
dc.source.endpage1480
refterms.dateFOA2020-09-28T11:34:52Z
dc.source.journaltitleChemistry (Weinheim an der Bergstrasse, Germany)
dc.source.countryUnited States
dc.source.countryUnited Kingdom
dc.source.countryUnited Kingdom
dc.source.countryGermany


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