Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1.
dc.contributor.author | Tungen, Jørn Eivind | |
dc.contributor.author | Gerstmann, Lisa | |
dc.contributor.author | Vik, Anders | |
dc.contributor.author | De Matteis, Roberta | |
dc.contributor.author | Colas, Romain Alexandre | |
dc.contributor.author | Dalli, Jesmond | |
dc.contributor.author | Chiang, Nan | |
dc.contributor.author | Serhan, Charles Nicholas | |
dc.contributor.author | Kalesse, Markus | |
dc.contributor.author | Hansen, Trond Vidar | |
dc.date.accessioned | 2020-09-28T11:34:51Z | |
dc.date.available | 2020-09-28T11:34:51Z | |
dc.date.issued | 2018-12-20 | |
dc.identifier.citation | Chemistry. 2019 Jan 28;25(6):1476-1480. doi: 10.1002/chem.201806029. Epub 2018 Dec 20. | en_US |
dc.identifier.pmid | 30511787 | |
dc.identifier.doi | 10.1002/chem.201806029 | |
dc.identifier.uri | http://hdl.handle.net/10033/622487 | |
dc.description.abstract | New drugs that can resolve inflammation without immunosuppressive effects are at the medicinal chemistry frontier. Pro-resolving endogenously formed small molecules, that is, the resolvins, are excellent candidates displaying such bioactions. The first total synthesis of the specialized pro-resolving mediator RvD1n-3 DPA has been achieved using the underutilized sp3 -sp3 Negishi cross coupling reaction and an alkyne hydrosilylation-protodesilylation protocol. Biological evaluations revealed that this novel mediator displays low nanomolar pro-resolving properties and potently activates the human DRV1/GPR32 receptor. As such, this endogenous natural product is a lead compound for the development of novel immunoresolvents. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.relation | info:eu-repo/grantAgreement/H2020/677542 | en_US |
dc.rights | openAccess | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Karstedt's catalyst | en_US |
dc.subject | natural products | en_US |
dc.subject | sp3-sp3 cross-coupling | en_US |
dc.subject | specialized pro-resolving mediators | en_US |
dc.subject | total synthesis | en_US |
dc.title | Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1. | en_US |
dc.type | Article | en_US |
dc.identifier.eissn | 1521-3765 | |
dc.contributor.department | HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany. | en_US |
dc.identifier.journal | Chemistry (Weinheim an der Bergstrasse, Germany) | en_US |
dc.source.volume | 25 | |
dc.source.issue | 6 | |
dc.source.beginpage | 1476 | |
dc.source.endpage | 1480 | |
refterms.dateFOA | 2020-09-28T11:34:52Z | |
dc.source.journaltitle | Chemistry (Weinheim an der Bergstrasse, Germany) | |
dc.source.country | United States | |
dc.source.country | United Kingdom | |
dc.source.country | United Kingdom | |
dc.source.country | Germany |