Show simple item record

dc.contributor.authorLinne, Yannick
dc.contributor.authorSchönwald, Axel
dc.contributor.authorWeißbach, Sebastian
dc.contributor.authorKalesse, Markus
dc.date.accessioned2020-10-01T14:17:55Z
dc.date.available2020-10-01T14:17:55Z
dc.date.issued2020-06-03
dc.identifier.citationChemistry. 2020 Jun 26;26(36):7998-8002. doi: 10.1002/chem.202000599.en_US
dc.identifier.pmid32068298
dc.identifier.doi10.1002/chem.202000599
dc.identifier.urihttp://hdl.handle.net/10033/622494
dc.description.abstractanti-Configured 1,3-dimethyl deoxypropionate motifs are important sub structures in natural products. Herein, we describe a bidirectional approach for the rapid construction of natural products featuring such motifs by using C2 -symmetrical 1,3-bis(boronic esters). As for its application in convergent syntheses it was important to establish a selective mono-Zweifel olefination we describe the scope and limitations by using different 1,3-bis(boronic esters) and nucleophiles. This protocol takes advantage of the combination of the Hoppe-Matteson-Zweifel chemistry, which was elegantly put into practice by Aggarwal et al. In order to show its applicability the total syntheses of two natural products, serricornin and (+)-invictolide, were performed.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectC2-symmetryen_US
dc.subjectdesymmetrizationen_US
dc.subjectlithiation-borylation chemistryen_US
dc.subjectmono-Zweifel olefinationen_US
dc.subjectnatural product synthesisen_US
dc.titleDesymmetrization of C -Symmetric Bis(Boronic Esters) by Zweifel Olefinations.en_US
dc.typeArticleen_US
dc.identifier.eissn1521-3765
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalChemistry (Weinheim an der Bergstrasse, Germany)en_US
dc.source.volume26
dc.source.issue36
dc.source.beginpage7998
dc.source.endpage8002
refterms.dateFOA2020-10-01T14:17:56Z
dc.source.journaltitleChemistry (Weinheim an der Bergstrasse, Germany)
dc.source.countryGermany


Files in this item

Thumbnail
Name:
Linne et al.pdf
Size:
2.652Mb
Format:
PDF
Description:
Open Access publication

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 4.0 International