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dc.contributor.authorShao, Lulu
dc.contributor.authorMarin-Felix, Yasmina
dc.contributor.authorSurup, Frank
dc.contributor.authorStchigel, Alberto M
dc.contributor.authorStadler, Marc
dc.date.accessioned2020-10-05T08:38:17Z
dc.date.available2020-10-05T08:38:17Z
dc.date.issued2020-09-25
dc.identifier.citationFungi (Basel). 2020 Sep 25;6(4):E188. doi: 10.3390/jof6040188.en_US
dc.identifier.pmid32992954
dc.identifier.doi10.3390/jof6040188
dc.identifier.urihttp://hdl.handle.net/10033/622495
dc.description.abstractDuring the course of a screening for novel biologically active secondary metabolites produced by the Sordariomycetes (Ascomycota, Fungi), the ex-type strain of Jugulospora vestita was found to produce seven novel xanthone-anthraquinone heterodimers, xanthoquinodin A11 (1) and xanthoquinodins B10-15 (2-7), together with the already known compound xanthoquinodin B4 (8). The structures of the xanthoquinodins were determined by analysis of the nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric data. Moreover, the absolute configurations of these metabolites were established by analysis of the 1H-1H coupling constants, nuclear Overhauser effect spectroscopy (NOESY) correlations, and Electronic Circular Dichroism (ECD) spectroscopic data. Antifungal and antibacterial activities as well as cytotoxicity of all compounds were tested. Xanthoquinodin B11 showed fungicidal activities against Mucor hiemalis [minimum inhibitory concentration (MIC) 2.1 µg/mL], Rhodotorula glutinis (MIC 2.1 µg/mL), and Pichia anomala (MIC 8.3 µg/mL). All the compounds 1-8 displayed anti-Gram-positive bacteria activity (MIC 0.2-8.3 µg/mL). In addition, all these eight compounds showed cytotoxicity against KB 3.1, L929, A549, SK-OV-3, PC-3, A431, and MCF-7 mammalian cell lines. The six novel compounds (1-3, 5-7), together with xanthoquinodin B4, were also found in the screening of other strains belonging to Jugulospora rotula, revealing the potential chemotaxonomic significance of the compound class for the genus.en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rightsAttribution-ShareAlike 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-sa/4.0/*
dc.subjectSordarialesen_US
dc.subjectantimicrobial activityen_US
dc.subjectcytotoxicityen_US
dc.subjectsecondary metabolitesen_US
dc.subjectxanthoquinodinsen_US
dc.titleSeven New Cytotoxic and Antimicrobial Xanthoquinodins from Jugulospora vestita.en_US
dc.typeArticleen_US
dc.identifier.eissn2309-608X
dc.contributor.departmentHZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.en_US
dc.identifier.journalJournal of fungi (Basel, Switzerland)en_US
dc.source.volume6
dc.source.issue4
refterms.dateFOA2020-10-05T08:38:18Z
dc.source.journaltitleJournal of fungi (Basel, Switzerland)
dc.source.countrySwitzerland


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